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Zinc Finger

Protein families, or protein domain families, are groups of protein domains that are related somehow, usually by gene families or evolutionary parameters. Proteins within a family have common ancestors from which they descend. This gives proteins within the same domain family similar three-dimensional structures, functions, and sequence similarities. Between 40 and 65% of proteins known will show sequence similarity to other proteins. When sequence similarity is known, structural and functional similarity is assumed. Zinc fingers are one such example of a protein domain family. Zinc fingers a group of transcription factors present in many different animals. The proteins are named for their finger like shape and their contents of at least one ion of zinc. There are approximately 6 subclasses of zinc fingers characterized by their "fold groups" and overall structural differences. These include the Cys2His2, gag knuckle, treble clef, zinc ribbon, Zn2/Cys6, and TAZ2 domains.

Anti-PRDM16 antibody binds against the target PRDM16. PRDM16 functions as a transcriptional regulator that binds to DNA. PRDM16 is localized in the cell nucleus and expressed in the cells of the uterus and kidney. PRDM16 functions in the differentiation of brown adipose (fat) tissue. The target specializes in dissipating chemical energy as heat in response to cold temperatures or excessive white adipose (fat) tissue metabolism. Defects with PRDM16 (chromosomal aberration) are involved in myelodysplastic syndrome and acute myeloid leukemia. Myelodysplastic syndromes are a group of diseases in which the bone marrow does not function properly. In individuals with myelodysplastic syndromes, their bone marrow does not make enough healthy blood cells. There are multiple types of MDS which are characterized by the appearance and types of blood cells that the bone marrow does produce. Treatment is available for MDS and includes chemotherapy, stem cell transplants, and use of growth factors. Acute myeloid leukemia is a cancer that also involves the bone marrow. AML is characterized by an abnormal accumulation of white blood cells in the bone barrow which interfere with the body's ability to produce normal blood cells. Treatment of AML typically consists of chemotherapy and in extreme cases, hematopoietic stem cell transplants. Anti-retinoic acid receptor alpha antibody binds against the target retinoic acid receptor alpha. Retinoic acid receptor alpha is a receptor for retinoic acid. Retinoic acid is a metabolite of vitamin A that referees vitamin A and its functions. Vitamin A is used to treat conditions like acne and even leukemia. Defects in the alpha retinoic acid receptor are commonly found in acute promyelocytic leukemia.

 
Product Number Title Applications Host Clonality
AC21-2660 Anti-ZBT24 Antibody ELISA, WB Goat Polyclonal
AC21-2682 Anti-PRDM16 Antibody ELISA, WB Goat Polyclonal
AC21-2691 Anti-Estrogen Receptor Beta Antibody ELISA, WB Goat Polyclonal
AC21-2724 Anti-HIC2 Antibody ELISA, WB Goat Polyclonal
AC21-2799 Anti-UHRF1 Antibody ELISA, WB Goat Polyclonal
AC21-2899 Anti-HIC1 Antibody ELISA, WB Goat Polyclonal
AC21-2900 Anti-HIC1 Antibody ELISA, WB Goat Polyclonal
AC21-2906 Anti-ZNF697 Antibody ELISA Goat Polyclonal
AC21-2967 Anti-CDKN1A Interacting Zinc Finger Protein 1 Antibody ELISA, WB Goat Polyclonal
AC21-0026-01 Anti-ZCH11 Antibody (AMCA) ELISA, IHC Goat Polyclonal
AC21-0026-02 Anti-ZCH11 Antibody (AP) ELISA, IHC Goat Polyclonal
AC21-0026-03 Anti-ZCH11 Antibody (APC) ELISA, IHC Goat Polyclonal