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WNT Signaling

Signal transduction refers to the process of signaling between cells or other molecules in the cellular environment that occurs when a surface cell receptor is activated by a molecule, such as an antibody, creating a response. The resulting action then mediates a reaction within the cell through a second messenger which elicits the physiological response. Along the way, amplification signals can be used to further facilitate the signal. WNT proteins are a family of signal molecules. These molecules are secreted by cells and used to regulate interactions from cell to cell during embryogenesis and adult cell proliferation. Wnt signaling pathways are extremely complicated and involve a large number of regulatory proteins in addition to the signaling molecules themselves. Mutations in the genes that encode for wnt proteins or in the pathways themselves are responsible for many detrimental diseases including cancer and developmental delays and defects.

Anti-dkk3 antibody binds against the target dickkopf 3. Dkk3 is a secreted protein that is involved in embryonic development through interacting with the Wnt signaling pathway. Dkk3 plays an integral role in vertebrate development and in adults, is involved in bone formation, bone disease, cancer, and Alzheimer's disease. Dickkopf3 is a secreted protein localized in the heart, brain, and spinal cord. Anti-frizzled 8 antibody binds against the target frizzled 8. Frizzled 8 is a member of the frizzled protein family which are signaling proteins forming transmembrane receptors. Frizzled 8 is highly expressed in human cancer of the brain, heart, kidney, pancreas, and certain skeletal muscles. Anti- frizzled 8 antibody binds to this protein and changes its formula for action.

 
Product Number Title Applications Host Clonality
AC21-1347-01 Anti-14-3-3 Tau Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-2662 Anti-HDAC1 Antibody ELISA, WB Goat Polyclonal
AC21-2678 Anti-Ryk Antibody ELISA Goat Polyclonal
AC21-2813 Anti-TCF4 Antibody ELISA, WB Goat Polyclonal
AC21-2874 Anti-Dishevelled / Dvl1 Antibody ELISA, WB Goat Polyclonal
AC21-0145-01 Anti-DKK2 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0145-02 Anti-DKK2 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0145-03 Anti-DKK2 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0145-04 Anti-DKK2 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0145-05 Anti-DKK2 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0145-06 Anti-DKK2 Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0145-07 Anti-DKK2 Antibody (Biotin) ELISA, WB Goat Polyclonal