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Ubiquitylation

Chromatin is the structure formed between DNA and proteins assembled in the cell’s nucleus. The nucleosome, the basic unit of chromatin, is highly condensed making the individual genetic material or genes on the DNA hidden or inaccessible by certain biological molecules. The DNA is wound around histone proteins. Chromatin modification involves enzymes that affect DNA transcription. Chromatin modifying enzymes essentially work to make the condensed chromatin accessible for transcription factors, DNA replication, recombination, and repair. There are many different surfaces to nucleosomes which provide many different binding sites for chromatin modifying enzymes. There are at least eight different classes of modifiers which have been characterized based on site and mechanism of action. These chromatin modifying enzymes have the potential to influence many fundamental biological processes of which some may be epigenetically inherited. Histone ubiquitylation is a chromatin post-translational modification that is a key regulator of gene expression and protein transcription. Ubiquitin itself is a relatively small (76 amino acids in length) protein. Enzymes like ubiquitin activating enzymes, ubiquitin conjugating nzymes, and ubiquitin ligases are responsible for the addition of ubiquitin molecules to histones. DNA ubiquitylation is implicated in a number of systems like DNA transcription, expression, and DNA repair.

Anti-TRIM37 antibody binds against the target tripartite motif containing 37. TRIM37 is localized in the cytoplasm and the peroxisome. It is ubiquitously expressed and functions as an E3 ubiquitin ligase. Defects in TRIM37 are implicated in mulibrey nanism. Mulibrey nanism is a very rare genetic disorder. Affected individuals have progressive growth failure, poor muscle tone, and a deformed skull. Anti-USP3 antibody binds against the target ubiquitin specific protease 3. USP3 is localized in the cell nucleus and expressed in all tissues especially the pancreas. Ubiquitin specific protease 3 is a hydrolase that deubiquitinates monoubiquinated target proteins such as histone H2A and H2B. USP3 may regulate the DNA damage response checkpoint through this deubuiquitination of H2A at sites where DNA damage is noted.

 
Product Number Title Applications Host Clonality
AC21-0233-01 Anti-UBE2C Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0233-02 Anti-UBE2C Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0233-03 Anti-UBE2C Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0233-04 Anti-UBE2C Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0233-05 Anti-UBE2C Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0233-06 Anti-UBE2C Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0233-07 Anti-UBE2C Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0233-08 Anti-UBE2C Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0233-09 Anti-UBE2C Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0233-10 Anti-UBE2C Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0233-11 Anti-UBE2C Antibody (Cy5.5) ELISA, WB Goat Polyclonal
AC21-0233-12 Anti-UBE2C Antibody (FITC) ELISA, WB Goat Polyclonal