Questions? Feedback? powered by Olark live chat software

Ubiquitin Related

Ubiquitin is a heat stable protein found in eukaryotes. It can be found in complexes with other proteins and free floating. Ubiquitin is involved in many cellular processes including mitosis, DNA repair, embryogenesis, and apoptosis. The main mechanism is to regulate the degradation of certain proteins in a process called protein turnover regulation. Ubiquitin assists in this, not by degrading the protein itself, but by tagging the protein for degradation by other cellular motors. When ubiquitin binds to molecules, they are effectively tagged and ready to be broken down or moved to other parts of the cell. Deubiquitination is the process by which the ubiquitin tag is removed and a molecule can be rescued from breakdown or removal. The ubiquitin protein itself is 76 amino acids in length and has a molecular mass of about 8.5 kDa. In mammals, there are 4 different genes that encode for ubiquitin. Ubiquitin related antibodies are useful in binding against ubiquitin and allowing scientists to determine the concentration of ubiquitin in a sample. Typically, this will indicate a disease process. Neurofibrillary tangles in Alzheimer’s disease, lewy bodies in Parkinson’s disease, pick bodies in Pick’s disease, and mallory bodies in alcoholic liver damage all exhibit abnormal accumulations of ubiquitin.

Anti-TRIM11 antibody binds against the target TRIM11. TRIM11 (ripartite motif containing 11) is an E3 ubiquitin-protein ligase that promotes the degradation of certain ubiquitinated proteins. TRIM11 is localized in the cytoplasm and nucleus of cells and is ubiquitously expressed in many tissues in the body. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. Anti-ITCH/AIP4 antibody binds against the target ITCH/AIP4. ITCH/AIP4 is localized on the cell membrane, in the cytoplasm, and in the nucleus. ITCH/AIP4 is an E3 ubiquitin-protein ligase and is widely expressed in many different tissues. Defects in ITCH are the cause of syndromic multisystem autoimmune disease (SMAD). Syndromic multisystem autoimmune disease is characterized by organomegaly, failure to thrive, developmental delay, dysmorphic features, and autoimmune inflammatory cell infiltration of the lungs, liver, and gut.

 
Product Number Title Applications Host Clonality
AC21-2631 Anti-TRIM11 Antibody ELISA, WB Goat Polyclonal
AC21-2649 Anti-RNF89 Antibody ELISA Goat Polyclonal
AC21-2776 Anti-PDLIM2 Antibody ELISA, WB Goat Polyclonal
AC21-2802 Anti-MKRN1 Antibody ELISA, WB Goat Polyclonal
AC21-2873 Anti-RNF70 Antibody ELISA Goat Polyclonal
AC21-2886 Anti-USP6 Antibody ELISA Goat Polyclonal
AC21-2894 Anti-ZNRF1 Antibody ELISA, WB, IHC Goat Polyclonal
AC21-0051-01 Anti-SHP2 Antibody (AMCA) ELISA, WB, IHC Goat Polyclonal
AC21-0051-02 Anti-SHP2 Antibody (AP) ELISA, WB, IHC Goat Polyclonal
AC21-0051-03 Anti-SHP2 Antibody (APC) ELISA, WB, IHC Goat Polyclonal
AC21-0051-04 Anti-SHP2 Antibody (APC-Cy5.5) ELISA, WB, IHC Goat Polyclonal
AC21-0051-05 Anti-SHP2 Antibody (APC-Cy7) ELISA, WB, IHC Goat Polyclonal