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Tyrosine Phosphatases

Human protein tyrosine phosphatases (PTPs) are key players in many different cellular occurrences. PTPs act on tyrosine phosphorylated proteins, aryl phosphates, and acyl phosphates. Together with protein tyrosine kinase, the main responsibility of PTPs is to catalyze the transfer of a phosphate group from those specific proteins to water creating an orthophosphate. Tyrosine phosphates are key enzymes in the catalysis of many signal transduction pathways, oncogenic transformation, and cell cycle control (cell growth, cellular differentiation, mitotic cycles). The PTP family is a diverse and large superfamily of proteins that contain receptor like PTPs as well as non-transmembrane PTPs. The enzymes, in the human genome, can be further classified into classical phophotyrosine specific phosphatases (pTyr) and dual specificity phosophatases (DSPs). Tyrosine phosphatase activity not only has the capacity to suppress certain types of disease but also defects in PTPs can be responsible for different types of human disease. Erroneous overexpression of cell-cycle regulatory phosphatase (aberrant upregulation) has been detected in many lines of cancer as well as certain autoimmunity disorders.

Anti-CD45 antibody (protein tyrosine phosphatase receptor type C antibody) binds against the target CD45 antigen. CD45 (leukocyte common antigen) is a protein tyrosine-protein phosphatase required to activate T-cells. CD45 is a positive regulator of T-cell coactivation that is localized in the membrane of cells. Once the T-cell has been activated by the CD45 activity, SKAP1 and FYN are recruited and dephosphorylated. Defects in protein tyrosine phosphatase receptor type C cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell positive and increase one's susceptibility to multiple sclerosis. Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell positive is a rare disease that presents with a fever, rash, hepatosplenomegal, lymphadenopathy, pneumonitis, and pancytopenia. It is a severe combined immunodeficiency. Multiple sclerosis is an inflammatory autoimmune disease characterized by plaques on the nerve fibers in the brain, spinal cord, and optic nerves. Anti-SET antibody binds against a target protein SET. SET is involved in apoptosis, transcription, nucleosome assembly, and histone binding. Both isoforms 1 and 2 of SET protein inhibit protein phosphatase and acetylation of histones and nucleosomes. The SET translocation protein mainly targets histone H4, and belongs to the nucleosome assembly protein (NAP) family. Anti-SET antibody functions in the cytoplasm, endoplasmic reticulum, and nucleus. SET is widely expressed in many tissues throughout the body. A chromosomal error involving the gene that codes for SET is sometimes responsible for causing acute undifferentiated leukemia. Acute undifferentiated leukemia, or stem cell leukemia, is characterized by acute myelogenous leukemia cells which are too immature to be classified.

 
Product Number Title Applications Host Clonality
AC21-0077-01 Anti-MTM1 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0077-02 Anti-MTM1 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0077-03 Anti-MTM1 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0077-04 Anti-MTM1 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0077-05 Anti-MTM1 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0077-06 Anti-MTM1 Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0077-07 Anti-MTM1 Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0077-08 Anti-MTM1 Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0077-09 Anti-MTM1 Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0077-10 Anti-MTM1 Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0077-11 Anti-MTM1 Antibody (Cy5.5) ELISA, WB Goat Polyclonal
AC21-0077-12 Anti-MTM1 Antibody (FITC) ELISA, WB Goat Polyclonal