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Tyrosine Kinases

Protein phosphorylation is the modification of post-translational proteins. This process is done by a group of enzymes called protein kinases. Phosphorylation is a reversible covalent modification. Tyrosine kinase is a protein kinase enzyme that can transfer a phosphate group from ATP to a protein in the cell. Protein tyrosine kinases, or PTKs, are enzymes that only phosphorylate at tyrosine residues. They are a subgroup of the main class of protein kinases which play an important role in signal transduction and cellular activity regulation. Tyrosine kinase inhibitors are useful in pharmaceuticals as drugs that can inhibit the action of tyrosine kinases. The mechanism of action can vary but ultimately tyrosine kinase inhibitors can compete with ATP, compete with the tyrosine kinase itself, block the phosphorylation site on the substrate, or bind to a site other than the phosphorylation site to cause a conformational change and thus make the phosphorylation site inaccessible. Tyrosine kinase antibodies can act as tyrosine kinase inhibitors or facilitators. These drugs have proven useful in cancer therapy, as chemotherapy agents, to block the cancer's ability to utilize tyrosine kinase and specifically target cancer cells and help to spare healthy tissues.

Anti-NIR1 antibody binds against NIR1 (membrane-associated 3 protein). NIR1 catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes and binds calcium ions. NIR1 is localized in the endomembrane system and detected in the brain, spleen, and ovary. Defects in NIR1 are the cause of cone-rod dystrophy. Cone-rod dystrophy is a progressive, inherited disease that causes deterioration of the cones and rods in the eye. This deterioration typically results in loss of color vision, visual acuity, peripheral vision, and night vision. CRDs are characterized by pigment deposits on the retina that are visible upon examination and can lead to complete loss of vision. . Anti-FGFR2 antibody binds against the target fibroblast growth factor receptor 2. FGFR2 is a receptor for acidic and basic fibroblast growth factors. Fibroblast growth factor receptor 2 is localized on the cell membrane of cells and is also secreted. Defects in FGFR2 are the cause of Crouzon syndrome, Apert syndrome, Pfeiffer syndrome, and familial scaphocephaly syndrome. Crouzon syndrome, also known as branchial arch syndrome, is a genetic disorder in which some of the skull bones fuse together prematurely which prevents normal scull growth. Affected individuals have distinct facial featurs like bulging ees, beaked nose, and underdeveloped jaws. Apert syndrome is similar to Crouzon syndrome. It is a genetic disorder that causes the skull bones to close earlier than normal and affects the shape of the head and face. Affected individuals may often also have fused fingers and fused toes. Pfeiffer syndrome and familial scaphocephaly syndrome, as well, have facial and cranial symptoms similar to those affected with Crouzon syndrome and branchial arch syndrome.

Product Number Title Applications Host Clonality
AC16-0055 Anti-VEGF Receptor 1 Antibody ELISA, WB, IHC(P), IP Rabbit Polyclonal
AC21-2651 Anti-LCK Antibody ELISA, WB Goat Polyclonal
AC21-2654 Anti-ZAP70 Antibody ELISA, WB Goat Polyclonal
AC21-2678 Anti-Ryk Antibody ELISA Goat Polyclonal
AC21-2814 Anti-ITK Antibody ELISA, WB Goat Polyclonal
AC21-2891 Anti-ROS Antibody ELISA Goat Polyclonal
AC21-2976 Anti-BCAR1 Antibody ELISA, WB Goat Polyclonal
AC21-0052-01 Anti-ITK Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0052-02 Anti-ITK Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0052-03 Anti-ITK Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0052-04 Anti-ITK Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0052-05 Anti-ITK Antibody (APC-Cy7) ELISA, WB Goat Polyclonal