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Tumor Suppressors

Tumor suppressors are the body’s way to prevent cancer from taking over. Cancer cells proliferate uncontrollably and monopolize the fuel that other typical cells need to function. Often times, these cancer cells result from cell division or other cell cycle processes gone awry. Some cells progress through the cell cycle unchecked and can go on to form malignant tumors. Luckily, the body has strict cancer prevention mechanisms which regulate the cell cycle. Tumor suppressor genes reduce the probability that a cell will turn into a tumor cell. Sometimes, though, these genes can mutate and be inherited from one generation to the next. These mutated tumor suppressor genes cannot encode for fully functioning tumor suppressors which can open the gates and allow cancer to take over. When functioning correctly tumor-suppressor proteins inhibit cell division. Cell division is inhibited, for instance, when the DNA in the cell is damaged. When the damage is unable to be repaired, the cell ought to die by apoptosis. When tumor suppressors are not functioning properly, the cell may be able to turn into cancer. Other tumor suppressors act by inhibiting the tumor cells ability to disperse by interfering with cell adhesion.

Anti-SMAD4 antibody binds against the target SMAD4. Smad 4 is localized in the cytoplasm and nucleus of a cell and is a co-activator and mediator of signal transduction by TGF-beta. Defects in SMAD4 are the cause of pancreatic cancer, juvenile polyposis syndrome, and juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome. Pancreatic cancer is cancer of the pancreas which is a large organ located behind the stomach responsible for releasing enzymes into the intestines that help the body absorb foods. Symptoms include dark urine, fatigue, jaundice, weight loss, and blood clots. Treatment is based on the progression of the disorder when diagnosed. Since pancreatic cancer is often advanced when first diagnosed, treatment may provide some relief but remission is achieved sporadically at best. Juvenile polyposis syndrome is characterized by multiple polyps in the gastrointestinal tract of a child or young adult. Hereditary hemorrhagic telangiectasia syndrome is a genetic disorder that leads to abnormal blood vessel formation in the skin, mucous membranes, and other organs. Symptoms include nosebleeds, digestive tract bleeding, and other organ issues. Anti-wilms tumor 1 antibody binds against a transcriptional regulator factor that plays an instrumental role in cellular development, specifically the urogenital system, and cell survival. The target protein has a tumor suppressor and thus plays a specific role in suppressing the formation of tumors and even in the formation of tumors (when the tumor suppressor malfunctions). There are many isoforms of this protein, and they tend to act differently. Particularly, certain isoforms will have a lower affinity or attraction to DNA but can bind to RNA as well. Defects in WT1 cause Frasier syndrome, Wilms Tumor 1, and Denys-Drash syndrome. Frasier syndrome is a urogenital disorder characterized genital tumors and male pseudohermaphroditism (where affected individuals are genotypically male however have external female characteristics). Wilms’ tumor is a cancer of the kidneys that usually occurs in children. Denys-Drash (although very rare) presents with gonadal dysgenesis, nephropathy, and tumors.

 
Product Number Title Applications Host Clonality
AC16-0045 Anti-KLF4 Antibody ELISA, WB Rabbit Polyclonal
AC16-0047 Anti-p53 Antibody ELISA, WB, IHC(F), IHC(P) Rabbit Polyclonal
AC16-0045-01 Anti-KLF4 Antibody (AMCA) ELISA, WB Rabbit Polyclonal
AC16-0045-02 Anti-KLF4 Antibody (AP) ELISA, WB Rabbit Polyclonal
AC16-0045-03 Anti-KLF4 Antibody (APC) ELISA, WB Rabbit Polyclonal
AC16-0045-04 Anti-KLF4 Antibody (APC-Cy5.5) ELISA, WB Rabbit Polyclonal
AC16-0045-05 Anti-KLF4 Antibody (APC-Cy7) ELISA, WB Rabbit Polyclonal
AC16-0045-06 Anti-KLF4 Antibody (Avidin) ELISA, WB Rabbit Polyclonal
AC16-0045-07 Anti-KLF4 Antibody (Biotin) ELISA, WB Rabbit Polyclonal
AC16-0045-08 Anti-KLF4 Antibody (BPE) ELISA, WB Rabbit Polyclonal
AC16-0045-09 Anti-KLF4 Antibody (Cy3) ELISA, WB Rabbit Polyclonal
AC16-0045-10 Anti-KLF4 Antibody (Cy5) ELISA, WB Rabbit Polyclonal