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Transcription Factors

DNA transcription is the copying of DNA into RNA by RNA polymerase. Transcription factors are proteins that bind to certain DNA sequences and are involved in the process of transcription. These factors will regulate what proteins within a cell are being manufactured. More specifically, they influence RNA polymerase to transcribe messenger RNA from certain genes. These factors can activate or repress the process of transcription. Activators effectively increase the rate at which genes are transcribed while repressors effectively decrease the rate of gene transcription. Transcription factors will bind to promoter regions of DNA. These promoter regions do not contain the actual DNA or genetic material for transcription but are rather adjacent to the gene. There are a number of anti- transcription factor antibodies useful that bind to these factors and are useful in research of transcription factors.

MeCP2 is a protein that binds to DNA and mediates the repression of transcription through involvement with histone deacetylase. Anti- MeCP2 antibody shows affinity to bind to MeCP2 protein. Defects in this protein are the cause of both Rett syndrome and Angelman syndrome (AS). Rett syndrome is a neurologic disorder which causes mental retardation, loss of speech, and seizures. AS is known as happy puppet syndrome and is similar to Rett syndrome. Autism X- linked type 3 is also thought to be caused by defects in MeCP2. The increased dosage of MeCP2 due to multiple copies of the gene (gene duplication) is thought to be the culprit in causing the mental retardation phenotypes. Anti- FOXP3 antibody detects a section of human FOXP3 protein. The FOXP3 protein is a transcription factor that controls certain immune responses and is thought to play a role in diabetes, infections (autoimmune and immunodeficiency), and anemia.

 
Product Number Title Applications Host Clonality
AC16-0036 Anti-SOX17 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0045 Anti-KLF4 Antibody ELISA, WB Rabbit Polyclonal
AC16-0036-01 Anti-SOX17 Antibody (AMCA) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-02 Anti-SOX17 Antibody (AP) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-03 Anti-SOX17 Antibody (APC) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-04 Anti-SOX17 Antibody (APC-Cy5.5) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-05 Anti-SOX17 Antibody (APC-Cy7) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-06 Anti-SOX17 Antibody (Avidin) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-07 Anti-SOX17 Antibody (Biotin) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-08 Anti-SOX17 Antibody (BPE) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-09 Anti-SOX17 Antibody (Cy3) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-10 Anti-SOX17 Antibody (Cy5) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)