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TNF

TNF’s are tumor necrosis factors. The entire class of tumor necrosis factors includes cytokines whose main function is to cause apoptosis. Cytokines are small proteins that are secreted by many types of cells, including monocytes and macrophages. They are involved in cell signaling and intracellular communication. Tumor necrosis factors have implications in tumor regression by causing tumor cells to die. There are many different members of the TNF family which include TNF-alpha, lymphotoxin-alpha, lymphotoxin-beta, FASL, and CD30L. Receptors for tumor necrosis factors exist on many different cell types as well as free floating in serums and solutions in the body. TNF antibodies bind against these necrosis factors and are used to treat a wide variety of diseases (mostly autoimmune disorders). For instance, TNF-alpha antibody is also known as Remicade or Infliximab (brand name Enbrel) and is used to treat psoriasis, Chohn’s disease, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis.

Anti-CIAS1 / NALP3 antibody binds against the target CIAS1. CIAS1 is an indicator of apoptosis that interacts with ASC and activates NF-kappa-B signaling. The target inhibits some of the functions of TNF-alpha. Defects in NLRP3 are the cause of familial cold auto inflammatory syndrome type 1, Muckle-Wells syndrome, and chronic infantile neurologic cutaneous and articular syndrome. Familial cold auto inflammatory syndrome type 1 is a type of periodic fever syndrome. Affected individuals suffer from rash, fever, and joint pains that are exacerbated by cold temperatures. Muckle-Wells syndrome is a rare autosomal dominant disorder characterized by sensorineural deafness, recurrent hives, fevers, chills, and painful joints. Chronic infantile neurologic cutaneous and articular syndrome is a very serious chronic inflammatory disease characterized by cutaneous symptoms, central-nervous system involvement, and arthropathy (joint disease). Anti-TNFRSF14 antibody binds against the target tumor necrosis factor receptor superfamily member 14. TNFRSF14 is localized on the cell membrane and expressed in a wide variety of tissues but in the highest amounts in the lung, spleen, and thymus.

 
Product Number Title Applications Host Clonality
AC16-0048 Anti-TNF Receptor I Antibody ELISA, WB, IHC(P), FC Rabbit Polyclonal
AC16-0059 Anti-TNF Receptor I Antibody ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0060 Anti-TNF Receptor I Antibody WB, IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (utr1)
AC16-0059-01 Anti-TNF Receptor I Antibody (AMCA) ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0059-02 Anti-TNF Receptor I Antibody (AP) ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0059-03 Anti-TNF Receptor I Antibody (APC) ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0059-04 Anti-TNF Receptor I Antibody (APC-Cy5.5) ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0059-05 Anti-TNF Receptor I Antibody (APC-Cy7) ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0059-06 Anti-TNF Receptor I Antibody (Avidin) ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0059-07 Anti-TNF Receptor I Antibody (Biotin) ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0059-08 Anti-TNF Receptor I Antibody (BPE) ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0059-09 Anti-TNF Receptor I Antibody (Cy3) ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)