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TGF Beta Signaling

TGF or transforming growth factor is categorized into two classes: alpha and beta. TGFs are proteins secreted by transformed cells that are able to stimulate growth in normal cells. For this reason, they are also called tumor growth factors. Both classes of TGFs are not really related to each other either structurally or genetically and they act through completely different mechanisms. However, they both have similar functions. Transforming growth factor alpha binds to epidermal growth factor receptors (EGFR) while transforming growth factor beta is found in hematopoietic tissue. Transforming growth factor alpha is a small protein that is 50 amino acids in length. High amounts of TGFa are characteristic in cancers but also play a role in healing wounds. Transforming growth factor beta is a regulatory cytokine whose main function is to maintain tolerance by regulating lymphocyte proliferation, differentiation, and survival. It is a secreted molecule classified into 3 different isoforms beta one, beta two, and beta three. TGF beta can bind to apoptosis receptors and induce apoptosis, cause protein synthesis and regulate the cell cycle, and regulate the immune system by activating lymphocyte and monocyte phagocytosis.

Anti-BMP5 Antibody binds against the target bone morphogeneteic protein 5. BMP 5 induces cartilage and bone formation. BMP5 is secreted by cells and expressed in the lung and liver. BMPs may also play a role in certain cancers. Anti-ERK2 antibody binds against the target extracellular signal related kinase 2. ERK2 is localized in the cell nucleus. ERK2 belongs to the protein kinase superfamily and the ser/thr protein kinase family. It is involved in the initiation and regulation of meiosis, mitosis, and postmitotic phosphorylation of many different transcription factors.

 
Product Number Title Applications Host Clonality
AC15-0116 Anti-TGF beta Antibody ELISA, WB, IHC, ICC, IF Chicken Polyclonal
AC21-2859 Anti-p15 INK4b Antibody ELISA, WB Goat Polyclonal
AC21-0063-01 Anti-SMAD2 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0063-02 Anti-SMAD2 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0063-03 Anti-SMAD2 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0063-04 Anti-SMAD2 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0063-05 Anti-SMAD2 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0063-06 Anti-SMAD2 Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0063-07 Anti-SMAD2 Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0063-08 Anti-SMAD2 Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0063-09 Anti-SMAD2 Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0063-10 Anti-SMAD2 Antibody (Cy5) ELISA, WB Goat Polyclonal