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Survivin Pathway

Survivin is a protein that in humans is encoded for by the BIRC5 (baculoviral inhibitor of apoptosis repeat containing 5) gene. There are 4 isoforms of the survivin protein. The main function of the protein revolves around apoptosis. Survivin has an apoptosis inhibitory affect. The surviving protein negatively regulates programmed cell death by inhibiting caspase activation. Survivin is present in almost, if not all, carcinomas or cancer cells. For this reason, survivin is a promising target for anti-cancer drug therapy. Suppressing survivin in cancer cells can ultimately lead to an increase in cell death of only those cancerous cells (not healthy tissues). The expression of surviving is highly regulated in the cell cycle.

Anti-survivin antibody binds against the target protein survivin. Survivin is localized in the cytoplasm, nucleus, chromosome, and centromere. Survivin is expressed in fetal kidney, liver, lung, brain, and most cancer cells. Anti-FAIM1 antibody binds against the target Fas apoptotic inhibitory molecule 1. FAIM1 is localized in the cytoplasm. It plays a role as an inducible effector molecule that mediates Fas resistance produced by surface immunoglobulin engagement in B cells.

 
Product Number Title Applications Host Clonality
AC21-0047-01 Anti-Livin Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0047-02 Anti-Livin Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0047-03 Anti-Livin Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0047-04 Anti-Livin Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0047-05 Anti-Livin Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0047-06 Anti-Livin Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0047-07 Anti-Livin Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0047-08 Anti-Livin Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0047-09 Anti-Livin Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0047-10 Anti-Livin Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0047-11 Anti-Livin Antibody (Cy5.5) ELISA, WB Goat Polyclonal
AC21-0047-12 Anti-Livin Antibody (FITC) ELISA, WB Goat Polyclonal