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SMADs

The large transforming growth factor beta is a superfamily of secreted proteins that regulate growth, development, and differentiation of cells in a variety of organisms. SMADs are a group of related intracellular proteins critical for transmitting to the nucleus signals from the transforming growth factor beta at the surface of cells. Essentially, they co-activate and mediate the signal transduction by TGF-beta. There are three classes: receptor-regulated, common-mediator, and antagonistic/inhibitory. They are related to each other but still have very different structures from each other and from other intracellular effector proteins. In mammals, there are 8 different smad family members (Smad2, Smad3, Smad1, Smad5, Smad8, Smad4, Smad6, and Smad7) which have been mapped to chromosomes 18, 15, 13, and 4. The main structure of the proteins includes an amino end and a carboxyl end that are separated by a proline-rich linker region of varying length.

Anti-SMAD4 antibody binds against the target SMAD4. Smad 4 is localized in the cytoplasm and nucleus of a cell and is a coactivator and mediator of signal transduction by TGF-beta. Defects in SMAD4 are the cause of pancreatic cancer, juvenile polyposis syndrome, and juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome. Pancreatic cancer is cancer of the pancreas which is a large organ located behind the stomach responsible for releasing enzymes into the intestines that help the body absorb foods. Symptoms include dark urine, fatigue, jaundice, weight loss, and blood clots. Treatment is based on the progression of the disorder when diagnosed. Since pancreatic cancer is often advanced when first diagnosed, treatment may provide some relief but remission is achieved sporadically at best. Juvenile polyposis syndrome is characterized by multiple polyps in the gastrointestinal tract of a child or young adult. Hereditary hemorrhagic telangiectasia syndrome is a genetic disorder that leads to abnormal blood vessel formation in the skin, mucous membranes, and other organs. Symptoms include nosebleeds, digestive tract bleeding, and other organ issues. Anti-nanog antibody binds against the target nanog. Nanog is localized in the cell nucleus and expressed in testicular cancer tumors, fetal gonads, and ovary cancer cells. Nanog is a transcription factor regulator involved in inner cell mass and embryonic stem cell proliferation and self-renewal.

 
Product Number Title Applications Host Clonality
AC21-0063-01 Anti-SMAD2 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0063-02 Anti-SMAD2 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0063-03 Anti-SMAD2 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0063-04 Anti-SMAD2 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0063-05 Anti-SMAD2 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0063-06 Anti-SMAD2 Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0063-07 Anti-SMAD2 Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0063-08 Anti-SMAD2 Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0063-09 Anti-SMAD2 Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0063-10 Anti-SMAD2 Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0063-11 Anti-SMAD2 Antibody (Cy5.5) ELISA, WB Goat Polyclonal
AC21-0063-12 Anti-SMAD2 Antibody (FITC) ELISA, WB Goat Polyclonal