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Serine and Threonine Phosphatases

Serine and threonine are amino acids of similar composition. Serine is non-essential and can be synthesized in the body from threonine or some other amino acids and necessary vitamins and/or minerals. Serine is useful in cells and contributes to the cell's flexibility in the cell membrane. It is also involved in DNA and RNA metabolism. Threonine is an amino acid found in certain meats, nuts, and seeds. It is also used to manufacture structural proteins and useful to propagate the immune system. Serine and threonine have similar side-chain compositions and thus can be phosphorylated by a single enzyme called serine/threonine protein kinase. The addition of the phosphate group can be reversed by an enzyme called serine/threonine phosphatase. The removal of the phosphate group helps to regulate many cellular pathways involved in cell proliferation, programmed cell death (apoptosis), embryonic development, and cell differentiation.

Anti-SET antibody, product number EB05148, binds against a target protein SET. SET is involved in apoptosis, transcription, nucleosome assembly, and histone binding. Both isoforms 1 and 2 of SET protein inhibit protein phosphatase and acetylation of histones and nucleosomes. The SET translocation protein mainly targets histone H4, and belongs to the nucleosome assembly protein (NAP) family. Anti-SET antibody functions in the cytoplasm, endoplasmic reticulum, and nucleus. SET is widely expressed in many tissues throughout the body. A chromosomal error involving the gene that codes for SET is sometimes responsible for causing acute undifferentiated leukemia. Acute undifferentiated leukemia, or stem cell leukemia, is characterized by acute myelogenous leukemia cells which are too immature to be classified. Anti-DUSP1 antibody binds against the target protein dual specificity phosphatase 1. DUSP1 contains one tyrosine-protein phosphatase domain and belongs to the protein-tyrosine phosphatase family. It is expressed in high levels in the lung, placenta, liver, and pancreas.

 
Product Number Title Applications Host Clonality
AC21-0031-01 Anti-AKAP12 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0031-02 Anti-AKAP12 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0031-03 Anti-AKAP12 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0031-04 Anti-AKAP12 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0031-05 Anti-AKAP12 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0031-06 Anti-AKAP12 Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0031-07 Anti-AKAP12 Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0031-08 Anti-AKAP12 Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0031-09 Anti-AKAP12 Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0031-10 Anti-AKAP12 Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0031-11 Anti-AKAP12 Antibody (Cy5.5) ELISA, WB Goat Polyclonal
AC21-0031-12 Anti-AKAP12 Antibody (FITC) ELISA, WB Goat Polyclonal