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Sensory System

The nervous system is an intricate, highly developed system that regulates and synchronizes the body's activities. The nervous system is an organ system which contains a grid of specialized neuronal cells called neurons. The human nervous system consists of two major parts called the central nervous system and the peripheral nervous system. The central nervous system in vertebrates contains the brain, spinal cord, and eyes. The peripheral nervous system contains sensory neurons which connect peripheral body parts to each other and to the central nervous system. It detects, transfers, and processes stimuli from the environment. The sensory system is part of the peripheral nervous system. The sensory system is composed of organs and tissues that provide the sensations from sight, hearing, smell, taste, and touch (along with the nerves and brain tissue that process the sensations). Stimuli are processed by way of a simple equation including detection of the stimulus, transmission, perception, and consciousness. Each step along the way is processed by cell bodies and synapses in the grey matter of the brain. The white matter, or myelinated axons, provide the pathways by which transmission can occur.

Anti-DYX1C1 antibody binds against the target dyslexia susceptibility 1 candidate. DYX1C1 is involved in neuronal migration during development of the cerebral neocortex. DYX1C1 is thought to regulate the stability and proteasomal degradation of estrogen receptors and plays an integral role in neuronal differentiation, survival, and plasticity. Dyslexia susceptibility 1 is localized in the cytoplasm and the nucleus of cells and is expressed in many tissues including the brain, lung, kidney, and testes. Defects in DYX1C1 cause susceptibility to dyslexia type 1. Dyslexia is a learning disability that can affect a person's ability to read, write, and speak properly. Typically dyslexia is diagnosed by measuring one's current reading level and comparing it to their reading potential (determined by an intelligence test). Primary dyslexia, or dyslexia type 1, is the genetic form of the disease and the most common form. Affected individuals typically have problems with identification of numbers and letters, spelling, and reading. Anti-myelin protein zero antibody binds against the target myelin protein zero. Myelin protein zero is localized on membranes and found only in the peripheral nervous system Schwann cells. The protein is implicated in creating the extracellular membrane face which can guide the wrapping process of adjacent lamellae. Defects in myelin protein zero are the ccause of Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, hypomyelination neuropathy, and Roussy-Levy syndrome. Charcot-Marie-Tooth disease is a group of genetic disorders that affects peripheral nerves. People affected with Charcot-Marie-Tooth disease experience a loss of touch sensation in the peripheral limbs and neuropathic pain. Dejerine-Sottas syndrome is a hereditary motor disease characterized by moderate to severe lower and upper extremity weakness. Onset occurs in infancy and early childhood with typically slow progression until the teenage years where the disease than progresses rapidly. Hypomyelination neuropathy is a neurological disorder present at birth characterized by respiratory difficulty, muscle weakness, and loss of coordination. Roussy-Levy syndrome is a neuromuscular disorder characterized by poor judgement of movement, absence of relexes, and muscle atrophy.

Product Number Title Applications Host Clonality
AC21-2706 Anti-TAS2R4 Antibody ELISA Goat Polyclonal
AC21-2856 Anti-Collagen XI alpha 2 Antibody ELISA Goat Polyclonal
AC21-2987 Anti-CORD2 Antibody ELISA, WB Goat Polyclonal
AC21-0213-01 Anti-PAX8 Antibody (AMCA) ELISA, WB, IHC Goat Polyclonal
AC21-0213-02 Anti-PAX8 Antibody (AP) ELISA, WB, IHC Goat Polyclonal
AC21-0213-03 Anti-PAX8 Antibody (APC) ELISA, WB, IHC Goat Polyclonal
AC21-0213-04 Anti-PAX8 Antibody (APC-Cy5.5) ELISA, WB, IHC Goat Polyclonal
AC21-0213-05 Anti-PAX8 Antibody (APC-Cy7) ELISA, WB, IHC Goat Polyclonal
AC21-0213-06 Anti-PAX8 Antibody (Avidin) ELISA, WB, IHC Goat Polyclonal
AC21-0213-07 Anti-PAX8 Antibody (Biotin) ELISA, WB, IHC Goat Polyclonal
AC21-0213-08 Anti-PAX8 Antibody (BPE) ELISA, WB, IHC Goat Polyclonal
AC21-0213-09 Anti-PAX8 Antibody (Cy3) ELISA, WB, IHC Goat Polyclonal