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The RNA interface, or RNAi, pathway refers to the introduction of double stranded RNA to target a gene's product. This results in different phenotypes which may be useless or only partially useful. By way of this process, cells can essentially moderate or modify the activity of their genes. This path is facilitated by the dicer enzyme which can cleave long molecules of double stranded RNA. RNAi is a key component in the immune response in plants to viruses and other foreign genetic material. Essentially, RNA interface works by extinguishing the messengers (messenger RNA molecules) that carry the information from genes to the ribosome to be made into proteins.

Anti-FMRP antibody binds against the target fragile X mental retardation protein. Fragile X mental retardation protein is localized in the cytoplasm of cells in the nucleus and nucleolus. FMRP is expressed in the highest levels in neurons, brain, testis, placenta, and lymphocytes but it is also expressed in epithelial tissues and in glial cells. Fragile X mental retardation protein is a translation repressor which binds to the mRNA cap which mediates translational repression and may also play a role in mRNA transport out of the nucleus into the cytoplasm. Defects in FMR1 are the cause of fragile X syndrome and premature ovarian failure syndrome type 1. Fragile X syndrome is a genetic disorder which affects the ordinary disposition of the X chromosome. The X chromosome is a sex chromosome present in both males and females (although females will have 2 copies of the X). The gene FMR1 (FMRP) can contain repeated segments. The more repeats the gene has, the more chances that the fragile areas of the X chromosome will contain defects. The proteins made by the FMR1 gene are required for proper brain growth. Females, having 2 X chromosomes, are less likely to be affected by one defective X, whereas males, having only 1 X chromosome, will become affected if their X chromosome is defective. Affected individuals suffer from delayed motor development, mental development, and social development. Physical signs include flat feet, low muscle tone, large forehead, and larger body size. Premature ovarian failure syndrome is also known as pre-mature or early menopause. Anti-dicer antibody binds against the target protein dicer. Dicer is localized in the cytoplasm. Defects in DICER1 are the cause of pleuropulmonary blastoma and goiter multinodular type 1. Pleuropulmonary blastoma is a rare type of lung tumor occurring in children that can be either benign or cancerous. The tumors originate in the lung tissue or in the cells of the tissue that surround the lungs (in the pleural cavity). PPB is a soft tissue cancer or sarcoma that is fundamentally different from other types of lung cancers. Multinodular goiter occurs in the excess of thyroid hormones. It is a form of hyperthyroidism characterized by nodules. Typically, goiters will become nodular with time. The incidence of goiter formation is also correlated with the amount of iodine in the diet, specifically iodine deficiency.

12 products match RPE
Product Number Title Applications Host Clonality
AC21-0491-21 Anti-elF4ENIF1 Antibody (RPE) ELISA, WB, IHC Goat Polyclonal
AC21-1047-21 Anti-Drosha Antibody (RPE) ELISA, WB Goat Polyclonal
AC21-1974-21 Anti-eIF5A Antibody (RPE) ELISA, WB Goat Polyclonal
AC21-0871-21 Anti-DCP1A Antibody (RPE) ELISA, WB Goat Polyclonal
AC21-1801-21 Anti-DGCR8 Antibody (RPE) ELISA Goat Polyclonal
AC21-0676-21 Anti-PIWIL1 Antibody (RPE) ELISA Goat Polyclonal
AC21-1048-21 Anti-DGCR8 Antibody (RPE) ELISA, WB Goat Polyclonal
AC17-0040-21 Anti-CASC3 Antibody (RPE) WB Rabbit Polyclonal
AC21-0873-21 Anti-Ago1 Antibody (RPE) ELISA, WB Goat Polyclonal
AC21-1888-21 Anti-FMRP Antibody (RPE) ELISA, WB Goat Polyclonal
AC21-0846-21 Anti-hUPF2/RENT2 Antibody (RPE) ELISA Goat Polyclonal
AC21-1213-21 Anti-FMRP Antibody (RPE) ELISA, WB Goat Polyclonal