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Regulatory T Cells

Immunology is the study of the immune system and its functions. The immune system can function in either specific, adaptive ways, or in innate or non-specific ways. The adaptive immune system involves complex antigen-specific immune responses which are specialized and exclusive to certain invaders like bacteria, viruses, and other pathogens. Adaptive immunity is remembered, meaning responses against a re-visiting antigen are increasingly speedy and effective with each future attack. This is due to the rearrangement of DNA in each cell that occurs after an adaptive immune response so that future generations may inherent the ability to combat the specific pathogen. During an initial acquired immunity response, antigens are presented to lymphoid organs (lymph nodes, spleen, tonsils, bone marrow, thymus, etc.) so that B-lymphocytes (B cells) and T-lymphocytes (T cells) can be differentiated into effector cells and reproduced. Precursors to T cells are produced in the bone marrow and matured in the thymus (hence their name "T" cell). T cells have a T cell receptor on their surface. Different types of T cells exist. These include helper T cells, cytotoxic T cells, memory T cells, regulatory T cells, and natural killer T cells. Each type of T cell has a specific function in the adaptive immune response. Regulatory T cells, or Tregs, help to maintain homeostasis among the different types of immune cells. They maintain peripheral tolerance, prevent autoimmune diseases, and limit chronic inflammatory diseases. In addition to their beneficial acts, they can also limit the immune response (especially the antitumor immune response).

Anti-B7H4 antibody binds against the target protein B7H4. B7H4 inhibits T-cell activation, proliferation, and development. By doing this, it negatively regulates the T-cell mediated immune response. B7H4 is localized on the cell membrane and expressed at the cell surface. The protein is overexpressed in breast, ovarian, endometrial, renal cell, and non-small-cell lung cancers. B7H4 is also expressed on activated T and B cells but not expressed in normal tissues. Anti-ikaros antibody binds against the target protein ikaros. Ikaros is localized in the cytoplasm and nucleus of cells and expressed in resting lmyphocyes in the thymus, spleen, and peripheral blood and lymph nodes. Ikaros is a transcription regulator of blood cell differentiation and plays a role in the development of B and T cells. Defects in ikaros are implicated in the occurance of acute lymphoblastic leukemia. Acute lymphoblastic leukemia is a form leukemia characterized by excess lymphoblasts. These cells are malignant white blood cells that are produced in excess by the bone marrow and infiltrate the body by traveling through the bloodstream. Symptoms include fatigue, anemia, fever, weight loss, bone pain, enlarged lymph nodes, and petechial.

 
Product Number Title Applications Host Clonality
AC16-0033 Anti-CD4 Antibody ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-01 Anti-CD4 Antibody (AMCA) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-02 Anti-CD4 Antibody (AP) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-03 Anti-CD4 Antibody (APC) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-04 Anti-CD4 Antibody (APC-Cy5.5) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-05 Anti-CD4 Antibody (APC-Cy7) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-06 Anti-CD4 Antibody (Avidin) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-07 Anti-CD4 Antibody (Biotin) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-08 Anti-CD4 Antibody (BPE) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-09 Anti-CD4 Antibody (Cy3) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-10 Anti-CD4 Antibody (Cy5) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-11 Anti-CD4 Antibody (Cy5.5) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
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