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Proteolytic Enzymes

Proteolysis is the term describing the digestion of proteins by enzymes called proteases- or proteolytic enzymes. These proteases break down proteins into their constituent parts of amino acids or smaller polypeptides. Proteolysis is implicated in many different processes inside the body including digestion, intracellular degradation, cell cycle regulation, and apoptosis. In human digestion, proteins are broken down by digestive enzymes like pepsin, trypsin, chymotrypsin, and elastase. This process starts in the stomach and the smaller nutrient parts are then absorbed in the small intestine. Intracellular proteolysis is helpful in removing damaged or abnormal proteins from the inside of cells. The lysosome and the proteasome assist in this process by engulphing proteins and using proteases like cathepsins to digest them. During the cell cycle, specific proteins called cyclins are able to activate kinases that are involved in cell division. In apoptosis, or programmed cell death, certain proteases called caspases assist in the processes of apoptosis.

Anti-AGBL5 antibody binds against the target ATP/GTP binding protein like 5. AGBL5 is a metallocarboxypeptidase that mediates tubulin deglutamylation. ATP/GTP binding protein like 5 is localized in the cytoplasm and in the nucleus and expressed in the brain. Anti-AGBL1 antibody binds against the target ATP/GTP binding protein like 1. AGBL1 is localized in the cytoplasm of cells. It belongs to the peptidase M14 family and is a metallocarboxylpeptidase that mediates the deglutamylation of target proteins.

 
Product Number Title Applications Host Clonality
AC16-0020 Anti-MMP3 Antibody ELISA, WB, IHC(F), IHC(P) Mouse Monoclonal (55-2A4)
AC16-0021 Anti-MMP2 Antibody IHC(F), IHC(P), FC Mouse Monoclonal (42-5D11)
AC16-0022 Anti-MMP9 Antibody WB, IHC(F), IHC(P) Mouse Monoclonal (56-2A4)
AC16-0023 Anti-MMP14 Antibody ELISA, WB, IHC(P) Mouse Monoclonal (114-1F2)
AC16-0024 Anti-MMP7 Antibody ELISA, WB, IHC(P), IP Mouse Monoclonal (141-7B2)
AC16-0025 Anti-MMP14 Antibody WB, IHC(P) Mouse Monoclonal (113-5B7)
AC16-0026 Anti-MMP15 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (162-22G5)
AC16-0027 Anti-MMP13 Antibody WB, IHC(F), IHC(P) Mouse Monoclonal (181-15A12)
AC16-0028 Anti-MMP7 Antibody WB, IHC(P) Mouse Monoclonal (176-5F12)
AC16-0029 Anti-MMP1 Antibody WB, IHC(F), IHC(P) Mouse Monoclonal (195-1H6)
AC16-0020-01 Anti-MMP3 Antibody (AMCA) ELISA, WB, IHC(F), IHC(P) Mouse Monoclonal (55-2A4)
AC16-0020-02 Anti-MMP3 Antibody (AP) ELISA, WB, IHC(F), IHC(P) Mouse Monoclonal (55-2A4)