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Protein Trafficking

Protein trafficking is the transport and movement of proteins throughout the cell or from the cell to the extracellular environment. The main cellular component, or organelle, involved in protein trafficking is the golgi body. Proteins that have been translated by the endoplasmic reticulum are first carried to the golgi apparatus by specialized vehicles called vesicles. The golgi body can modify the proteins if need be. The golgi apparatus is essentially a dynamic network of endomembrane which can form vesicles to transport proteins. It can access proteins brought to it by fusing with the transport vesicles. Within the golgi apparatus, the proteins are modified and sorted depending upon their final destination, and then packaged in vesicles and sent on their way.

Anti-hsp22 antibody binds against the target hsp22 antigen. Hsp22, or alpha crystalline C chain, is localized in the cytoplasm and nucleus and is predominantly expressed in skeletal muscle and the heart. Hsp22 is a chaperone protein that is dependent on temperature. Defects in HSPB8 are the cause of distal hereditary motor neuronopathy and Charcot-Marie-Tooth disease. Hereditary motor neuronopathy is a rare disorder characterized by distal weakness and wasting in the limbs with no significant sensory involvement. Charcot-Marie-Tooth disease is a group of genetic disorders that affects peripheral nerves. People affected with Charcot-Marie-Tooth disease experience a loss of touch sensation in the peripheral limbs and neuropathic pain. Anti-SRD5A2 antibody binds against the target steroid 5 alpha reductase 2. SRD5A2 converts testosterone into DHT and progesterone or corticosterone and plays a central role in sexual differentiation and androgen physiology. SRD5A2 is expressed in the prostate and localized on the microsome and endoplasmic reticulum membranes. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias. Pseudovaginal perineoscrotal hypospadias is an abnormal arrangement of external genetalia. Individuals affected with pseudovaginal perineoscrotal hypospadias typically have somewhat male and somewhat female genetalia which has been linked to 5-alpha-reductase deficiency.

 
Product Number Title Applications Host Clonality
AC16-0011 Anti-P4HB Antibody WB Mouse Monoclonal (3-2B12)
AC16-0014 Anti-P4HB Antibody ELISA, WB, IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (6-9H6)
AC16-0011-01 Anti-P4HB Antibody (AMCA) WB Mouse Monoclonal (3-2B12)
AC16-0011-02 Anti-P4HB Antibody (AP) WB Mouse Monoclonal (3-2B12)
AC16-0011-03 Anti-P4HB Antibody (APC) WB Mouse Monoclonal (3-2B12)
AC16-0011-04 Anti-P4HB Antibody (APC-Cy5.5) WB Mouse Monoclonal (3-2B12)
AC16-0011-05 Anti-P4HB Antibody (APC-Cy7) WB Mouse Monoclonal (3-2B12)
AC16-0011-06 Anti-P4HB Antibody (Avidin) WB Mouse Monoclonal (3-2B12)
AC16-0011-07 Anti-P4HB Antibody (Biotin) WB Mouse Monoclonal (3-2B12)
AC16-0011-08 Anti-P4HB Antibody (BPE) WB Mouse Monoclonal (3-2B12)
AC16-0011-09 Anti-P4HB Antibody (Cy3) WB Mouse Monoclonal (3-2B12)
AC16-0011-10 Anti-P4HB Antibody (Cy5) WB Mouse Monoclonal (3-2B12)