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Protein Phosphorylation

Protein phosphorylation is the modification of post-translational proteins. This process is done by a group of enzymes called protein kinases. Phosphorylation is a reversible covalent modification. The inverse of phosphorylation (de-phosphorylation) is carried out by a group of enzymes called protein phosphatases. The addition or removal of the phosphate itself can act as a protein regulator. It can essentially switch on or off, or regulate in other ways, specific functions of many proteins. Depending on the size of the protein, there can be multiple phosphorylation sites. Essentially, the state in which the target protein resides in (phosphorylated, or de-phosphorylated) can determine the function for that protein at the time. Although there are many, many different protein kinases, there are only a few dozen types of protein phosphatases.

Anti-NIR1 antibody binds against NIR1 (membrane-associated 3 protein). NIR1 catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes and binds calcium ions. NIR1 is localized in the endomembrane system and detected in the brain, spleen, and ovary. Defects in NIR1 are the cause of cone-rod dystrophy. Cone-rod dystrophy is a progressive, inherited disease that causes deterioration of the cones and rods in the eye. This deterioration typically results in loss of color vision, visual acuity, peripheral vision, and night vision. CRDs are characterized by pigment deposits on the retina that are visible upon examination and can lead to complete loss of vision. Anti-IRAK4 Antibody binds against interleukin 1 receptor associated kinase 4. IRAK4 triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization and phosphorylates IRAK1. Defects in IRAK4 cause recurrent isolated invasive pneumococcal disease type 1 and IRAK4 deficiency. Recurrent isolated invasive pneumococcal disease type 1 occurs when the individual has two episodes of IPD occurring at least one month apart. IPD, or invasive pneumococcal disease, is an infection caused by streptococcus pneumonia which results in pneumonia, sepsis, ear infection, and bacterial meningitis. IRAK4 deficiency is very rare inherited disorder of the immune system which leads to recurrent infections by pyogenic (puss producing) bacteria.

 
Product Number Title Applications Host Clonality
AC16-0055 Anti-VEGF Receptor 1 Antibody ELISA, WB, IHC(P), IP Rabbit Polyclonal
AC21-2646 Anti-STK3 Antibody ELISA, WB Goat Polyclonal
AC21-2651 Anti-LCK Antibody ELISA, WB Goat Polyclonal
AC21-2652 Anti-JNK2 Antibody ELISA, WB Goat Polyclonal
AC21-2653 Anti-JNK2 Antibody ELISA, WB Goat Polyclonal
AC21-2654 Anti-ZAP70 Antibody ELISA, WB Goat Polyclonal
AC21-2678 Anti-Ryk Antibody ELISA Goat Polyclonal
AC21-2697 Anti-DAGK Antibody ELISA Goat Polyclonal
AC21-2803 Anti-PIM2 Antibody ELISA, WB Goat Polyclonal
AC21-2814 Anti-ITK Antibody ELISA, WB Goat Polyclonal
AC21-2821 Anti-TRIB1 Antibody ELISA, WB Goat Polyclonal
AC21-2847 Anti-PIM2 Antibody ELISA, WB Goat Polyclonal
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