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Pol II Transcription

Pol II, or RNA polymerase II, is an enzyme that facilitates the transcription of DNA to synthesize smaller RNA precursors to mRNA, snRNA, and microRNA. In the eukaryotic genome, there are thousands of different genes that encode for RNA polymerase II. Pol II is a 12-subunit DNA-dependent RNA polymerase. Pol II is responsible for transcribing all of the protein-coding genes. Unlike RNA polymerase I and RNA polymerase III, pol II cannot act alone to transcribe those smaller RNA precursors. Transcription factors are necessary to initiate a multi-protein DNA complex to commence transcription. In addition to transcription factors, transcriptional activators and co-activators are necessary. There are many complicated steps in the process of transcription by pol II. Along the way, there are many checks and balances to insure the process is moving along properly.

Anti-ILF2 antibody binds against the target interleukin enhancer binding factor 2. ILF2 functions as a heterodimeric complex with ILF3. The complex composed of ILF2 and ILF3 regulates transcription of the IL2 gene during T-cell activations and can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Interleukin enhancer binding factor 2 is localized in the nucleus and the cytoplasm. The anti-Von Hippel Lindau antibody has involvement in cancer, metabolism, transcription, and cell-cycle functions. Also known as the VHL antibody, it can bind to the von Hippel-Lindau ugiquitination complex. The target protein is involved in the ubiquitination and proteasomal degradation of the VHL complex. Defects in this complex cause von Hippel-Lindau disease, pheochromocytoma, and erythrocytosis familial type 2. VHL is a rare genetic disorder in which affected individuals develop abnormal tumor growth in multiple parts of the body. Pheochromocytoma is a rare tumor of the adrenal gland which results in excess epinephrine and norepinephrine transmission. It is characterized by irregular heart rate, upset metabolism, and blood pressure. Erythrocytosis familial type 2 is an autosomal recessive genetic disorder which causes red blood cells to increase in mass. Complications of this disease include peripheral thrombosis and cerebrovascular events.

 
Product Number Title Applications Host Clonality
AC21-2656 Anti-TATA Binding Protein TBP Antibody ELISA, WB Goat Polyclonal
AC21-2657 Anti-TATA Binding Protein TBP Antibody ELISA, WB Goat Polyclonal
AC21-2698 Anti-UBN1 Antibody ELISA, WB Goat Polyclonal
AC21-2704 Anti-FUBP1 Antibody ELISA, WB Goat Polyclonal
AC21-2852 Anti-MED12 Antibody ELISA Goat Polyclonal
AC21-2954 Anti-ASC1 Antibody ELISA Goat Polyclonal
AC21-2955 Anti-ASC1 Antibody ELISA Goat Polyclonal
AC21-2958 Anti-BATF Antibody ELISA Goat Polyclonal
AC21-0238-01 Anti-IRF2 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0238-02 Anti-IRF2 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0238-03 Anti-IRF2 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0238-04 Anti-IRF2 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal