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PE-Dyomics 647 Antibodies

Conjugated antibodies are antibodies that have been joined or conjugated to a type of second molecule. The second molecule can be a toxin, radioisotope, or other label. Abcore-Inc. offers numerous conjugated antibodies that come labeled with a fluorescent dye and proteins. Conjugated antibodies are also called immonoconjugates and are mostly used in immunotherapy or in development of antibodies used to target specific tissues. There are a few, more newly developed, combination conjugates which include PerCP-Cy5.5, PE-Cy™5, PE-Dyomics 647, PE-Dyomics 590. PE-Dyomics 647 is a dual conjugate that can be attached to antibodies. Phycoerythrin, often abbreviated PE, is a fluorescent dye. PE is comparatively larger than many other types of conjugates and has a molecular weight of 240 kd. The molecule itself contains 25 fluors. Dyomics 647 absorbs and emits light at 653 nm and 672 nm respectively (in Ethanol). Dy-647 is a pentamethine based bluorophore that is soluble in water, methanol, DMF, and DMSO. It produces a red excitation by way of laser. Dy-647 is a pentamethine based fluorophore. The PE-Dyomics 647 combination has an excitation wavelength of 488nm and an emission wavelength of 672 nm.

Anti-CD10 (PE-Dyomics 647) antibody binds against CALLAS (common acute lymphoblastic leukemia antigen). Common acute lymphoblastic leukemia antigen is a characterization of leukemias and lymphomas in blood. CALLA has a thermolysin-like specificity but prefers to act against polypeptides of a particular size (up to 30 amino acids in length). CD10 is located on the cell membrane and is part of the peptidase M13 family. Anti-CD45 (PE-Dyomics 647) antibody (protein tyrosine phosphatase receptor type C antibody) binds against the target CD45 antigen. CD45 (leukocyte common antigen) is a protein tyrosine-protein phosphatase required to activate T-cells. CD45 is a positive regulator of T-cell coactivation that is localized in the membrane of cells. Once the T-cell has been activated by the CD45 activity, SKAP1 and FYN are recruited and dephosphorylated. Defects in protein tyrosine phosphatase receptor type C cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell positive and increase one’s susceptibility to multiple sclerosis. Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell positive is a rare disease that presents with a fever, rash, hepatosplenomegal, lymphadenopathy, pneumonitis, and pancytopenia. It is a severe combined immunodeficiency. Multiple sclerosis is an inflammatory autoimmune disease characterized by plaques on the nerve fibers in the brain, spinal cord, and optic nerves.

 
Product Number Title Applications Host Clonality
1Y-202 Anti-CD3 Antibody (PE-Dyomics 647) IP, FC, FUNC Mouse Monoclonal (MEM-57)
1Y-399 Anti-CD16 Antibody (PE-Dyomics 647) IP, FC Mouse Monoclonal (LNK16)
1Y-366 Anti-CD38 Antibody (PE-Dyomics 647) WB, IHC(F), IHC(P), FC Mouse Monoclonal (HIT2)
1Y-359 Anti-CD4 Antibody (PE-Dyomics 647) WB, FC Mouse Monoclonal (MEM-241)
1Y-343 Anti-CD63 Antibody (PE-Dyomics 647) WB, IHC(P), ICC, IP, FC Mouse Monoclonal (MEM-259)
1Y-326 Anti-IgE Antibody (PE-Dyomics 647) ELISA, FC Mouse Monoclonal (4H10)
1Y-324 Anti-IgE Antibody (PE-Dyomics 647) ELISA, FC Mouse Monoclonal (BE5)
1Y-305 Anti-CD19 Antibody (PE-Dyomics 647) IP, FC Mouse Monoclonal (LT19)
1Y-297 Anti-CD34 Antibody (PE-Dyomics 647) WB, IHC(P), FC Mouse Monoclonal (4H11[APG])
1Y-207 Anti-CD8 Antibody (PE-Dyomics 647) IP, FC Mouse Monoclonal (MEM-31)
1Y-585 Anti-ENPP3 Antibody (PE-Dyomics 647) FC Mouse Monoclonal (NP4D6)