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PE-Dyomics 590 Antibodies

Conjugated antibodies are antibodies that have been joined or conjugated to a type of second molecule. The second molecule can be a toxin, radioisotope, or other label. Abcore-Inc. offers numerous conjugated antibodies come labeled with a fluorescent dye and proteins. Conjugated antibodies are also called immonoconjugates and are mostly used in immunotherapy or in development of antibodies used to target specific tissues. There are a few, more newly developed, combination conjugates which include PerCP-Cy5.5, PE-Cy™5, PE-Dyomics 647, PE-Dyomics 590. PE-Dyomics 590 is a dual conjugate that can be attached to antibodies. Phycoerythrin, often abbreviated PE, is a fluorescent dye. PE is comparatively larger than many other types of conjugates and has a molecular weight of 240 kd. The molecule itself contains 25 fluors. Dyomics 590, or Dy-590, has a maximum absorption of 580 nm and a maximum emission at 599 nm. It is soluble in methanol, DMF, and DMSO. The tandem PE-Dyomics 590 also has a maximum emission at 599 nm but with a lower maximum absorption at 488 nm. PE-Dyomics 590 tandem dyes exhibit the very similar spectral properties to PE-Texas Red tandem dyes.

Anti-CD45 (PE-Dyomics 590) antibody (protein tyrosine phosphatase receptor type C antibody) binds against the target CD45 antigen. CD45 (leukocyte common antigen) is a protein tyrosine-protein phosphatase required to activate T-cells. CD45 is a positive regulator of T-cell coactivation that is localized in the membrane of cells. Once the T-cell has been activated by the CD45 activity, SKAP1 and FYN are recruited and dephosphorylated. Defects in protein tyrosine phosphatase receptor type C cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell positive and increase one’s susceptibility to multiple sclerosis. Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell positive is a rare disease that presents with a fever, rash, hepatosplenomegal, lymphadenopathy, pneumonitis, and pancytopenia. It is a severe combined immunodeficiency. Multiple sclerosis is an inflammatory autoimmune disease characterized by plaques on the nerve fibers in the brain, spinal cord, and optic nerves. Anti-CD20 (PE-Dyomics 590) antibody binds against CD20. CD 20 is involved in the regulation of B-cell activation and proliferation. B lymphocyte antigen CD20 is expressed on B-cell membranes. Defects in the gene that encodes for CD20 are the cause of immunodeficiency common variable type 5. Common variable immune deficiency is characterized by humoral immune deficiency which results in an individual’s susceptibility to infections and decreased response to vaccinations. Common variable immune deficiency has better outcomes than agammaglobulinemia wherein affected individuals often have amounts of circulating B cells in the normal-low range and suffer from frequent bacterial infections.

 

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