Questions? Feedback? powered by Olark live chat software

Oxidative Stress

Oxidative stress occurs when there is an imbalance between the production of oxygen and the body’s ability to detoxify it. Certain forms of oxygen can be reactive and therefore extremely toxic to tissues in the body. This toxicity can cause damage. The oxidative stress ensues when the body attempts to detoxify the oxygen and repair the damage that it causes. The damage is caused by the production of peroxides and free radicals that damage all cells and their components including proteins, lipids, and even DNA. Oxidative stress is involved in many different types of disease including heart failure, atherosclerosis, and Alzheimer’s disease. The effects of oxidative stress include DNA damage, necrosis, ATP depletion, and apoptic death.

Anti-PARK7/DJ1 antibody binds against the target protein Parkinson protein 7. Park 7 is encoded by the gene PARK7 and protects cells against oxidative stress and cell death. Park 7 has a number of very important functions which include eliminating hydrogen peroxide from cells, regulating mitochondrial morphology and function, destroying dysfunctional mitochondria, and regulating astrocyte inflammatory responses. Park7 is localized in the nucleus, mitochondria, and cytoplasm of cells. This protein is highly expressed in the pancreas, kidney, skeletal muscle, liver, testis, and heart. Defects in PARK7 are the cause of early onset Parkinson’s disease. Anti-PRODH antibody binds against the target proline dehydrogenase (oxidase) 1. PRODH is localized on the matrix of the mitochondria and expressed in lung, skeletal muscle, brain, heart, and kidney tissues. Defects in PRODH are the cause of hyperprolinemia type 1 and susceptibility to schizophrenia type 4. People with hyperprolinemia type 1 are often asymptomatic, and thus sometimes go undiagnosed. Affected individuals have increased levels of proline in their blood. When symptoms are seen, they include seizures, mental retardation, and neurological problems. Schizophrenia is a mental disorder characterized by difficulties perceiving reality including auditory hallucinations, delusions, and disorganized speech.

 
Product Number Title Applications Host Clonality
AC16-0031 Anti-Nitrotyrosine Antibody IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0032 Anti-Nitrotyrosine Antibody ELISA, WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (2E11-3D3)
AC16-0031-01 Anti-Nitrotyrosine Antibody (AMCA) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0031-02 Anti-Nitrotyrosine Antibody (AP) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0031-03 Anti-Nitrotyrosine Antibody (APC) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0031-04 Anti-Nitrotyrosine Antibody (APC-Cy5.5) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0031-05 Anti-Nitrotyrosine Antibody (APC-Cy7) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0031-06 Anti-Nitrotyrosine Antibody (Avidin) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0031-07 Anti-Nitrotyrosine Antibody (Biotin) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0031-08 Anti-Nitrotyrosine Antibody (BPE) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0031-09 Anti-Nitrotyrosine Antibody (Cy3) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)
AC16-0031-10 Anti-Nitrotyrosine Antibody (Cy5) IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6B2-3G2)