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Organogenesis

Organogenesis is the process by which the ectoderm, endoderm, and mesoderm develop into the internal organs of an organism. The ectoderm, endoderm, and mesoderm are the germ layers of the developing gastrula. Organogenesis occurs between the 3rd and 8th week in utero. Organogenesis is part of the process of embryogenesis when the germ layers differentiate into the embryo that will eventually grow to be the entire organism. The first stage in vertebrate organogenesis is called neurulation. This is characterized by the folding of the neural plate which forms the neural tube.

Anti-MSX1 antibody binds against the target msh homeobox 1 like protein. This protein is localized in the cell nucleus and expressed in the developing nail bed mesenchyme. MSH homeobox 1 like protein acts as a transcriptional repressor and plays a role in limb-pattern formation. Defects in MSX1 are the cause of tooth agenesis selective type 1, Witkop syndrome, and non-syndromic orofacial cleft type 5. Tooth agenesis selective type 1 is a form of selective tooth agenesis characterized by congential absence of one or more teeth. Witkop syndrome, or “tooth and nail syndrome”, is a rare disorder characterized by weak, thin nails of small size along with the absence of certain teeth. Non-syndromic orofacial cleft type 5 is a common birth defect consisting of cleft lips with or without a cleft palate. Anti-pax3 antibody binds against the target pax3 (paired box protein 3). Pax3 functions as a transcription factor associated with the development of alveolar rhabdomyosarcoma. Paired box protein 3 is localized in the cell nucleus. Defects in PAX3 are the cause of Waardenburg syndrome, craniofacial-deafness-hand syndrome, and rhabdomyosarcoma. Waardenburg syndrome is a genetic syndrome with a variety of related defects. Waardenburg syndrome is characterized by partial albinism, wide set eyes, and deafness. Craniofacial-deafness-hand syndrome is characterized by distinctive facial features, hearing loss, and hand abnormalities. Affected individuals have a flat facial profile, slit like nostrils, and loss of hearing. Rhabdomyosarcoma is a cancerous tumor that is attached to the bone inside of the muscle. Rhabdomyosarcoma is a rare form of cancer treated with radiation or chemotherapy or a combination of both.

 
Product Number Title Applications Host Clonality
AC15-0116 Anti-TGF beta Antibody ELISA, WB, IHC, ICC, IF Chicken Polyclonal
AC16-0038 Anti-MyoD1 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0063 Anti-Smoothelin Antibody WB, IHC(F), IHC(P), ICC, IF, FC, FUNC Mouse Monoclonal (R4A)
AC16-0038-01 Anti-MyoD1 Antibody (AMCA) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0038-02 Anti-MyoD1 Antibody (AP) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0038-03 Anti-MyoD1 Antibody (APC) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0038-04 Anti-MyoD1 Antibody (APC-Cy5.5) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0038-05 Anti-MyoD1 Antibody (APC-Cy7) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0038-06 Anti-MyoD1 Antibody (Avidin) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0038-07 Anti-MyoD1 Antibody (Biotin) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0038-08 Anti-MyoD1 Antibody (BPE) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0038-09 Anti-MyoD1 Antibody (Cy3) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)