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Nucleotide Metabolism

Similar to other bodily processes, nucleotides have dietary needs or metabolic requirements that in a whole make up nucleotide metabolism. A nucleotide is a molecule consisting of a nitrogenous base and a five-carbon sugar. Genetic material (such as DNA) and other signaling molecules (like RNA) are both composed of nucleotides. Both DNA and RNA can be carriers for cellular energy and thus also play a major role in cellular metabolism. The requirements for nucleotide metabolism are either met by dietary consumption or synthesized by the nucleotides themselves using precursor molecules (these precursors are typically incomplete or damaged nucleotides). Nucleic acids taken in by the diet are then hydrolyzed with the help of endonucleases, phosphodiesterases, and nucleoside phosphorylases. These pathways yield oligonucleotides which are further broken down by phosphodiesterases which digest inward releasing the free nucleosides. These can be further hydrolyzed to yield free bases and used as needed by the nucleotide metabolic paths. The nucleotides that are unavailable by way of dietary consumption, purine and pyrimidine, can be salvaged and repaired or synthesized. This process occurs for the most part in the liver and utilizes cellular energy in the form of ATP.

Anti-TFB2M antibody binds against the target transcription factor B2 (mitochondrial). TFB2M is localized on the mitochondria and ubiquitously expressed in all tissues. TFB2M is required for basal transcription of mitochondrial DNA and stimulates transcription of methyltransferase. Anti-PGC1 alpha binds against the target peroxisome proliferate activated receptor gamma coactivator 1 alpha. PGC1 alpha is a transcriptional coactivator for steroid and nuclear receptors. PGC1 alpha facilitates the activity of PPARG and thyroid hormone receptor. The target can also regulate key mitochondrial genes that contribute to adaptive thermogenesis. PGC1 alpha is localized in the nucleus of cells and expressed in the heart, skeletal muscle, liver, and kidney. In skeletal muscle, the amount of PGC1 alpha was lower in obese people than in lean people. Fasting in obese subjects induced a 200% increase in the levels.

 
Product Number Title Applications Host Clonality
AC21-0262-01 Anti-TFB2M Antibody (AMCA) ELISA, ICC Goat Polyclonal
AC21-0262-02 Anti-TFB2M Antibody (AP) ELISA, ICC Goat Polyclonal
AC21-0262-03 Anti-TFB2M Antibody (APC) ELISA, ICC Goat Polyclonal
AC21-0262-04 Anti-TFB2M Antibody (APC-Cy5.5) ELISA, ICC Goat Polyclonal
AC21-0262-05 Anti-TFB2M Antibody (APC-Cy7) ELISA, ICC Goat Polyclonal
AC21-0262-06 Anti-TFB2M Antibody (Avidin) ELISA, ICC Goat Polyclonal
AC21-0262-07 Anti-TFB2M Antibody (Biotin) ELISA, ICC Goat Polyclonal
AC21-0262-08 Anti-TFB2M Antibody (BPE) ELISA, ICC Goat Polyclonal
AC21-0262-09 Anti-TFB2M Antibody (Cy3) ELISA, ICC Goat Polyclonal
AC21-0262-10 Anti-TFB2M Antibody (Cy5) ELISA, ICC Goat Polyclonal
AC21-0262-11 Anti-TFB2M Antibody (Cy5.5) ELISA, ICC Goat Polyclonal
AC21-0262-12 Anti-TFB2M Antibody (FITC) ELISA, ICC Goat Polyclonal