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Nuclear Signaling

There are numerous signaling pathways in the body. These include (but are certainly not limited to) calcium signaling, G protein signaling, lipid signaling, and nuclear signaling. Nuclear signaling involves the transport of certain molecules in and/or out of the nucleus. The nucleus is bound by a membrane called the nuclear membrane or nuclear envelope. In the envelope, there are pores which can allow for transport or signaling between the components of the nucleus and the components of the cell. Smaller molecules can flow freely by way of diffusion, while larger molecules are assisted by specific transport receptors. These nuclear signaling receptors make it easier for larger molecules, like microRNAs, to communicate signals between the nucleus and the cell.

Anti-androgen receptor antibody binds against the androgen receptor. Androgen receptors are steroid hormone receptors that are activated by ligand transcription factors and regulate gene expression, cellular proliferation, and differentiation in target tissues. Androgen receptors are localized in the nucleus and cytoplasm of the heart and skeletal muscles. Defects in AR are the cause of androgen insensitivity syndrome, spinal and bulbar muscular atrophy X-linked type 1, and metastatic prostate cancer. Individuals affected with androgen insensitivity syndrome are genetically male but are resistant to male androgen hormones. The resulting phenotype is a person that looks physically like a woman but has the genetic makeup of a man (no uterus and lack of fertility and menstruation). Treatment sometimes includes removal of inguinal testicles and estrogen replacement therapy. Spinal and bulbar muscular atrophy X-linked type 1 is a debilitating neurodegenerative disease. Affected individuals suffer from muscle ramps and degeneration of motor neurons leading to progressive weakness. Metastatic prostate cancer is an advanced form of prostate cancer. Anti-SOCS3 antibody binds against the target SOCS3. SOCS3 is expressed in the heart, placenta, skeletal muscle, peripheral blood leukocytes, lung, and kidney. It is a negative regulator of cytokines. Defects in SOCS3 are implicated in atopic dermatitis. Atopic dermatitis is a chronic skin disorder that involves scaly and itchy rashes. Symptoms include blisters, discharge, raw skin, redness, and inflammation.

 
Product Number Title Applications Host Clonality
AC21-2691 Anti-Estrogen Receptor Beta Antibody ELISA, WB Goat Polyclonal
AC21-2730 Anti-NCKAP1 Antibody ELISA Goat Polyclonal
AC21-2806 Anti-CIKS Antibody ELISA, WB Goat Polyclonal
AC21-2850 Anti-TORC2 Antibody ELISA, WB Goat Polyclonal
AC21-2857 Anti-NAK Antibody ELISA, WB Goat Polyclonal
AC21-2861 Anti-STAT5a Antibody ELISA, WB Goat Polyclonal
AC21-2961 Anti-IFNAR1 Antibody ELISA Goat Polyclonal
AC21-2962 Anti-IFNAR1 Antibody ELISA, WB Goat Polyclonal
AC21-2963 Anti-IFNAR1 Antibody ELISA, WB Goat Polyclonal
AC21-2967 Anti-CDKN1A Interacting Zinc Finger Protein 1 Antibody ELISA, WB Goat Polyclonal
AC21-0018-01 Anti-SOCS3 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0018-02 Anti-SOCS3 Antibody (AP) ELISA, WB Goat Polyclonal