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Nuclear Receptors

The nuclear receptor superfamily is a class of ligand activated transcriptional regulators in animals. The nuclear receptors have the ability to regulate numerous functions such as homeostasis, reproduction, development, and metabolism. The receptors themselves are proteins that can bind against hormones and other ligands. Nuclear receptors are unique in that they have the ability to bind directly to DNA molecules and thereby regulate the expression of genes. The majority of classified nuclear receptors have no known ligands and are termed orphans. There are two main classifications of nuclear receptors and they include steroid hormone receptors and retinoid/thyroid/vitamin D receptors.

Anti-androgen receptor antibody binds against the androgen receptor. Androgen receptors are steroid hormone receptors that are activated by ligand transcription factors and regulate gene expression, cellular proliferation, and differentiation in target tissues. Androgen receptors are localized in the nucleus and cytoplasm of the heart and skeletal muscles. Defects in AR are the cause of androgen insensitivity syndrome, spinal and bulbar muscular atrophy X-linked type 1, and metastatic prostate cancer. Individuals affected with androgen insensitivity syndrome are genetically male but are resistant to male androgen hormones. The resulting phenotype is a person that looks physically like a woman but has the genetic makeup of a man (no uterus and lack of fertility and menstruation). Treatment sometimes includes removal of inguinal testicles and estrogen replacement therapy. Spinal and bulbar muscular atrophy X-linked type 1 is a debilitating neurodegenerative disease. Affected individuals suffer from muscle ramps and degeneration of motor neurons leading to progressive weakness. Metastatic prostate cancer is an advanced form of prostate cancer. Anti-CBL antibody binds against the target CBL. CBL has a role in signal transduction in hematopoietic cells. CBL is an adapter protein that can negatively regulate many different signaling pathways by binding to receptors on the surface of cells. CBL is localized in the cytoplasm of cells. Defects in CBL are the cause of Noonan syndrome-like disorder. Noonan syndrome is an autosomal dominant congenital disorder considered to be a type of dwarfism. Symptoms include delayed puberty, hearing loss, mental retardation, short stature, and physical anomalies including wide-set eyes, abnormally shaped ears, and sagging eyelids. Affected individuals may suffer from complications like excess fluid buildup in bodily tissues, infertility, heart problems, and social issues. There is no treatment or cure, but individuals who have a family history of Noonan syndrome can engage in genetic testing or counseling before having children who may inherit the disorder.

 
Product Number Title Applications Host Clonality
AC21-2691 Anti-Estrogen Receptor Beta Antibody ELISA, WB Goat Polyclonal
AC21-2850 Anti-TORC2 Antibody ELISA, WB Goat Polyclonal
AC21-2967 Anti-CDKN1A Interacting Zinc Finger Protein 1 Antibody ELISA, WB Goat Polyclonal
AC21-0116-01 Anti-CBL Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0116-02 Anti-CBL Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0116-03 Anti-CBL Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0116-04 Anti-CBL Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0116-05 Anti-CBL Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0116-06 Anti-CBL Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0116-07 Anti-CBL Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0116-08 Anti-CBL Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0116-09 Anti-CBL Antibody (Cy3) ELISA, WB Goat Polyclonal