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Neurotrophins

Neurotrophins are proteins that help nerve cells determine whether they will live or die. They are secreted by the nervous system and in low concentrations are necessary to keep nerve cells alive. Neurtotrophins in different concentrations can also initiate cell death. Neurotrophins have many other important functions including development regulation, maintenance, and determining function of vertebrate nervous systems. They activate different types of receptors and the delicate balance in neutrophin amounts insure that there is a match between the amount of neurons and the amount of targets. The proteins themselves are considered growth factors which are secreted and capable of signaling. They are approximately 120 amino acids in length and typically produced by cleaving longer protein precursors. There are different subtypes of neurotrophins including nerve growth factors (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NGF's are secreted by a neuron's target cell and necessary for the survival of sympathetic and sensory neurons. BDNFs are typically found in the brain and act mainly upon the axons, dendrites, and synapses between cells in the central nervous system (and to a lesser extent those in the peripheral nervous system). NT-3 and NT-4 are subclasses that act on certain neurons and typically can also activate particular tyrosine kinase pathways and receptors.

Anti-neuturin antibody binds against the target neuturin. Neuturin belongs to the TGF-beta family and is secreted by cells. It helps to support the survival of sympathetic neurons and may regulate and maintain neurons in the central nervous system. Defects in NRTN are the cause of Hirschsprung disease. Hirschsprung disease is a disorder of the gastrointestinal system. The large intestine of affected individuals has no nerves and thus cannot function properly. These nerves are necessary to control the action of the colon. Stool cannot pass because the colon cannot relax when necessary. Symptoms include green or brown vomit, abdomen swelling, gas, and bloody diarrhea. Treatment includes surgical procedures like ostomy or colon pull through. Anti-BDNF antibody binds against the target brain derived neurotrophic factor. BDNF is secreted by cells and expressed in the brain, heart, lung, skeletal muscle, testis, prostate, and placenta. BDNF is a neutrophin that promotes the survival and differentiation of certain neuronal populations. Defects in BDNF are the cause of central hypoventilation syndrome. Central hypoventilation syndrome, also called Ondine's curse, is a potentially fatal respiratory disorder. Affected individuals lack the automatic control of respiration that most people enjoy. Typically, one can sleep or go about their day without having to mentally think about and control the lungs to breathe. Those with central hypoventilation syndrome can suddenly stop breathing, especially while sleeping. This disease can sometimes be accompanied by Hirschsprung disease.

 
Product Number Title Applications Host Clonality
AC21-0717-01 Anti-p75 NGF Receptor Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0717-02 Anti-p75 NGF Receptor Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0717-03 Anti-p75 NGF Receptor Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0717-04 Anti-p75 NGF Receptor Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0717-05 Anti-p75 NGF Receptor Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0717-06 Anti-p75 NGF Receptor Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0717-07 Anti-p75 NGF Receptor Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0717-08 Anti-p75 NGF Receptor Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0717-09 Anti-p75 NGF Receptor Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0717-10 Anti-p75 NGF Receptor Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0717-11 Anti-p75 NGF Receptor Antibody (Cy5.5) ELISA, WB Goat Polyclonal
AC21-0717-12 Anti-p75 NGF Receptor Antibody (FITC) ELISA, WB Goat Polyclonal