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Neuroregeneration

Neuroregeneration is the regrowth or repair of nervous system tissues like neurons and parts of neuronal cells. This can occur in the central nervous system as well as the peripheral nervous system. When injuries to nerves in the peripheral nervous system occur, neroregeneration can occur. For instance, when axons are damaged, axonal sprouts are produced which can connect the severed ends. In the central nervous system, regeneration is much less frequent. Typically when neuron damage occurs in the brain or spine, the damaged neuron is targeted, regeneration is inhibited, and scar tissue forms. Current research has identified many different molecules which facilitate neurogenesis in the developing brain. However, these molecules also inhibit neuroregeneration in the adult nervous system. Neuroregeneration research in adult tissues focuses on protecting nerves from damage, replacing the damaged cells, stimulating regrowth of axons, directing that regrowth to form functional connections with target cells, and retraining dormant neural circuits. Neuroregeneration antibodies are in the spotlight in this research. Certain antibodies have shown to play a critical role in repairing the myelin sheath in nerve cells. One day, this may result in non-invasive treatments to promote nerve regeneration.

Anti-ROBO1 antibody binds against the target roundabout 1 (roundabout axon guidance receptor homolog 1). Robo1 is localized on the cell membrane and expressed in many different tissues, with the exception of the kidney tissues. Roundabout 1 is a receptor for SLIT1 and SLIT2. SLIT1 and SLIT2 are molecular guidance cues in cellular migration including axonal navigation during neuronal development. Anti-myelin oligodendrocyte glycoprotein antibody binds against the target myelin oligodendrocyte glycoprotein. MOG is found on the cell membrane of cells exclusively in the central nervous system. It is localized exlusively on myelin and oligodendrocyte cytoplasmic membranes. Myelin oligodendrocyte glycoprotein mediates hemophilic cell to cell adhesion and is a major component of the myelin sheath.

 
Product Number Title Applications Host Clonality
AC21-0671-01 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0671-02 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0671-03 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0671-04 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0671-05 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0671-06 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0671-07 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0671-08 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0671-09 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0671-10 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0671-11 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (Cy5.5) ELISA, WB Goat Polyclonal
AC21-0671-12 Anti-Myelin Oligodendrocyte Glycoprotein Antibody (FITC) ELISA, WB Goat Polyclonal