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Neuroreceptors and Channels

Receptors are found on the surface of cells and have numerous functions. They act as binding sites or antigens to antibodies and other ligands and can communicate signals within a cell or between cells and even allow for transport of molecules into and out of the cell. Receptors are made of proteins and act as ligands to other proteins, molecules, drugs, or toxins. Basically, the ligand will bind to the receptor and form a ligand-receptor complex. Certain ligands can activate a receptor. These are called agonists. Other ligands will deactivate or block the receptor from having a certain action. These are called antagonists. Antibodies can serve as binding materials and can also be agonists or antagonists. Receptor structure varies depending on the classification of the certain receptor. There are receptors that merely sit on the surface of cells and receptors that go across the external cellular membrane. These include G-protein coupled receptors and ligand- gated ion channels. Neuroreceptors are receptors for neurotransmitters in the brain. These receptors are activated solely by neurotransmitters like serotonin, dopamine, norepinephrine, and histamine. Some of these receptors are ligand-gated ion channels which are transmembrane ion channels which can either be opened or closed in response to the binding of the chemical neurotransmitter.

The anti-clusterin antibody attaches to the clusterin protein. The first isoform is a chaperone protein that stops non-native proteins from attaching to the cell. In actuality, this prevents the aggregation of blood plasma proteins from attaching during stress-induced situations. This protein does not require ATP to function. When this protein is secreted by cells it prevents the apoptosis process. There are other nuclear forms of clusterin that promote apoptosis. Anti-HCG receptor antibody binds against the HCG gonadotropin receptor. The HCG receptor is localized on the cell membrane and specified in gonadal and thyroid cells. The HCG receptor is a receptor for lutropin-choriogonadotropic hormone which is mediated by G proteins which activate adenylate cyclase. Defects in LHCGR are the cause of familial male precocious puberty (testotoxicosis) and luteinizing hormone resistance. Testotoxicosis is a state of male puberty that is characterized by an increased production of androgen. This increased androgen level requires the treatment by anti-androgens in order to slow the pubertal rate and as a result, also slowing skeletal growth. Male precosious puberty typically manifests itself in boys between the ages of 2 and 4. Affected individuals have accelerated growth, early sexual development, and astonishingly reduced adult height.

 
Product Number Title Applications Host Clonality
AC21-2635 Anti-ABCC9 Antibody ELISA Goat Polyclonal
AC21-2638 Anti-Serotonin Transporter Antibody ELISA, WB Goat Polyclonal
AC21-2659 Anti-P2RX4 Antibody ELISA, WB Goat Polyclonal
AC21-2706 Anti-TAS2R4 Antibody ELISA Goat Polyclonal
AC21-2711 Anti-Muscarinic Acetylcholine Receptor 2 Antibody ELISA, WB Goat Polyclonal
AC21-2741 Anti-5HT2A Receptor Antibody ELISA Goat Polyclonal
AC21-2756 Anti-Alpha 1 Glycine Receptor Antibody ELISA, WB Goat Polyclonal
AC21-2757 Anti-HRH3 Antibody ELISA, WB Goat Polyclonal
AC21-2775 Anti-CD97 Antibody ELISA, WB Goat Polyclonal
AC21-2788 Anti-Alpha 1B Adrenergic Receptor Antibody ELISA, WB Goat Polyclonal
AC21-2789 Anti-Alpha 1B Adrenergic Receptor Antibody ELISA, WB Goat Polyclonal
AC21-2790 Anti-Alpha 1 Adrenergic Receptor Antibody ELISA, WB Goat Polyclonal