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Neuronal Stem Cells

Stem cells are undifferentiated cells that have the capability to differentiate into specialized cell types. Stem cells are found in embryos during the blastocyte phase and also in adult tissue. A blastocyte is a 4 or 5 day old embryo. These stem cells can be harvested from embryos produced during the in-vitro fertilization process which may not be implanted or used in assisted reproduction attempts. The harvesting of embryonic stem cells does destroy the embryo. Embryonic stem cells have the potential to become any cell in the body. Stem cells can also be harvested from umbilical cord blood during birth. These cells can be less malleable, but still useful in treating certain diseases, especially leukemias. The cord blood stem cells are picked out in a sea of other typical blood cells. Adult stem cells are found in organs that have the capability to renew or regenerate themselves. Adult stem cells, or somatic stem cells, are most commonly found in bone marrow, brain tissue, blood, skeletal muscles, skin, teeth, and testis. Once removed from the body, however, adult stem cells quickly lose their ability to differentiate. Neuronal stem cells are a type of stem cell characterized by their ability to differentiate into neurons, astrocytes, and oligodendrocytes.

Anti-pax3 antibody binds against the target pax3 (paired box protein 3). Pax3 functions as a transcription factor associated with the development of alveolar rhabdomyosarcoma. Paired box protein 3 is localized in the cell nucleus. Defects in PAX3 are the cause of Waardenburg syndrome, craniofacial-deafness-hand syndrome, and rhabdomyosarcoma. Waardenburg syndrome is a genetic syndrome with a variety of related defects. Waardenburg syndrome is characterized by partial albinism, wide set eyes, and deafness. Craniofacial-deafness-hand syndrome is characterized by distinctive facial features, hearing loss, and hand abnormalities. Affected individuals have a flat facial profile, slit like nostrils, and loss of hearing. Rhabdomyosarcoma is a cancerous tumor that is attached to the bone inside of the muscle. Rhabdomyosarcoma is a rare form of cancer treated with radiation or chemotherapy or a combination of both. Anti-FLAP antibody binds against the target FLAP. FLAP (ALOX5AP) functions as a membrane anchor by anchoring ALOX5 to the membrane. FLAP is required for leukotriene biosynthesis because it binds to MK-886 which is a compound that will block leukotriene biosynthesis. FLAP is localized in the nucleus membrane, and the endoplasmic reticulum. Defects in FLAP may be one cause of susceptibility to ischemic stroke and susceptibility to myocardial infarction. Ischemic stroke occurs when blood supply to the brain is interrupted depriving the brain cells of vital oxygen. This disruption is due to a blocked or burst blood vessel in the brain. In ischemic stroke, the cause is a blood clot, wherein a hemorrhagic stroke is caused by a burst vessel. Myocardial infarction is a heart attack. Heart attacks result when the blood supply to a part of the heart is interrupted causing damage to the heart.

 
Product Number Title Applications Host Clonality
AC21-2642 Anti-PAX3 Antibody ELISA, WB Goat Polyclonal
AC21-2786 Anti-EAAT1 Antibody ELISA, WB Goat Polyclonal
AC21-2787 Anti-EAAT1 Antibody ELISA, WB Goat Polyclonal
AC21-2795 Anti-Transferrin Receptor Antibody ELISA, WB Goat Polyclonal
AC21-0181-01 Anti-Cystatin C Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0181-02 Anti-Cystatin C Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0181-03 Anti-Cystatin C Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0181-04 Anti-Cystatin C Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0181-05 Anti-Cystatin C Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0181-06 Anti-Cystatin C Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0181-07 Anti-Cystatin C Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0181-08 Anti-Cystatin C Antibody (BPE) ELISA, WB Goat Polyclonal