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Neuronal Growth

The nervous system is an intricate, highly developed system that regulates and synchronizes the body's activities. The nervous system is an organ system which contains a grid of specialized neuronal cells called neurons. The human nervous system consists of two major parts called the central nervous system and the peripheral nervous system. The central nervous system in vertebrates contains the brain, spinal cord, and eyes. The peripheral nervous system contains sensory neurons which connect peripheral body parts to each other and to the central nervous system. Neurons, whether in the peripheral or central nervous system, function by transmitting chemical and/or electrical signals between each other, typically across a space called a synapse. Chemical messengers involved in the signal transmission between neurons are called neurotransmitters. Disorders of the nervous system, or neuronal diseases, can be caused by many different mechanisms. The nervous system is vulnerable to trauma, infections, degenerations, structural defects, tumors, blood flow disruption, and autoimmune disorders. Neurodegenerative diseases include a class of disorders of the brain that involve the degeneration of neurons or other signaling capabilities in the central nervous system. There are several causes of neurodegenerative diseases which include genetics and injury. Most neurons are developed during gestation and the earlier stages of embryogenesis. The nervous system is derived from the outer most tissue layer, the ectoderm. After the development of these undifferentiated nerve cells, or stem cell precursors, the differentiation can occur. This is when the migration of these immature nerve cells can move to their final destinations and continue to mature. This occurs when the neuronal axons sprout from the immature cells and elongate through the surrounding tissues to reach their closest neighbors. This happens then the tip of the neuron elongates into a structure called a neuron growth cone. The growth cone can advance and turn until it reaches its proper destination.

Anti-slit2 antibody binds against the target protein slit 2. Slit2 is secreted by sales and expressed in fetal lung and kidney as well as adult spinal cord. Slit2 acts as a molecular cue to guide cellular migration during neural development. Anti-DCTN1 antibody binds against the target dynactin 1. DCTN1 is localized in the cytoplasm and cytoskeleton and expressed in the brain. Dynactin 1 is required for the retrograde movement of vesicles and organelles along microtubules. Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B, amyotrophic lateral sclerosis (ALS), and Perry syndrome. Distal hereditary motor neuronopathy type 7B is a neuromuscular disorder caused by selective degeneration of motor neurons in the anterior horn of the spinal cord. Initially, affected individuals experience weakness of distal muscles and lower extremities which progresses later on to atrophy in proximal muscles and the distal upper limbs. Amyotrophic lateral sclerosis, also called Lou Gehrig's disease, is a disease of the nerve cells in the brain and spinal column. These neurons misfire and cause loss of voluntary muscle movement. Symptoms of ALS include difficulty breathing, muscle cramps, paralysis, speech problems, and weight loss. Perry syndrome is a progressive brain disease that is characterized by movement abnormalities, psychiatric changes, weight loss, and slow breathing.

Product Number Title Applications Host Clonality
AC21-2734 Anti-UNC5B Antibody ELISA Goat Polyclonal
AC21-2749 Anti-CNTN4 Antibody ELISA, WB Goat Polyclonal
AC21-2820 Anti-EDG8 Antibody ELISA, WB Goat Polyclonal
AC21-2950 Anti-Netrin G1 Antibody ELISA Goat Polyclonal
AC21-0258-01 Anti-DCTN1 Antibody (AMCA) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0258-02 Anti-DCTN1 Antibody (AP) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0258-03 Anti-DCTN1 Antibody (APC) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0258-04 Anti-DCTN1 Antibody (APC-Cy5.5) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0258-05 Anti-DCTN1 Antibody (APC-Cy7) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0258-06 Anti-DCTN1 Antibody (Avidin) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0258-07 Anti-DCTN1 Antibody (Biotin) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0258-08 Anti-DCTN1 Antibody (BPE) ELISA, WB, IHC, ICC Goat Polyclonal