Questions? Feedback? powered by Olark live chat software

Neurodegenerative Diseases

The nervous system is an intricate, highly developed system that regulates and synchronizes the body's activities. The nervous system is an organ system which contains a grid of specialized neuronal cells called neurons. The human nervous system consists of two major parts called the central nervous system and the peripheral nervous system. The central nervous system in vertebrates contains the brain, spinal cord, and eyes. The peripheral nervous system contains sensory neurons which connect peripheral body parts to each other and to the central nervous system. Neurons, whether in the peripheral or central nervous system, function by transmitting chemical and/or electrical signals between each other, typically across a space called a synapse. Chemical messengers involved in the signal transmission between neurons are called neurotransmitters. Disorders of the nervous system, or neuronal diseases, can be caused by many different mechanisms. The nervous system is vulnerable to trauma, infections, degenerations, structural defects, tumors, blood flow disruption, and autoimmune disorders. Neurodegenerative diseases include a class of disorders of the brain that involve the degeneration of neurons or other signaling capabilities in the central nervous system. There are several causes of neurodegenerative diseases which include genetics and injury. Also, because the amount of nerve cells a person is born with stays stable throughout their lives (for the most part, brain cells and other peripheral neurons are not regenerated or created later in life), neural degeneration like Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, and Alzheimer's are progressive and irreversible types of neuronal disease or dysfunction.

The anti- neuroserpin antibody has roles in serine protease inhibitors. It may be involved in the protein that reorganizes synaptic connections and protects neurons from cell damage. Defects in neuroserpin cause genetic encephalopathy characterized by inherited dementia. The notch 2 protein is a receptor on the membrane of cells and binds to ligands and anti- notch 2 antibodies. These proteins regulate the fate of the cell by influencing processes including differentiation, proliferation, and apoptosis specifically of osteoclasts or bone cells. Defects in NOTCH2 cause Alagille syndrome type 2 and Hajdu-Cheney syndrome (HJCYS). HJCYS is a skeletal disorder. Hajdu-Cheney syndrome affected individuals have facial defects, osteoporosis, acro-osteolysis, and periodontal disease. Alagille syndrome type 2 is a form of arteriohepatic dysplasia which involves multisystem defects characterized by chronic cholestasis due to paucity of intrahepatic bile ducts, peripheral pulmonary artery stenosis, and dysplastic kidneys. Alagille syndrome type 2 is inherited by an autosomal dominant fashion. Anti-myelin protein zero antibody binds against the target myelin protein zero. Myelin protein zero is localized on membranes and found only in the peripheral nervous system Schwann cells. The protein is implicated in creating the extracellular membrane face which can guide the wrapping process of adjacent lamellae. Defects in myelin protein zero are the cause of Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, hypomyelination neuropathy, and Roussy-Levy syndrome. Charcot-Marie-Tooth disease is a group of genetic disorders that affects peripheral nerves. People affected with Charcot-Marie-Tooth disease experience a loss of touch sensation in the peripheral limbs and neuropathic pain. Dejerine-Sottas syndrome is a hereditary motor disease characterized by moderate to severe lower and upper extremity weakness. Onset occurs in infancy and early childhood with typically slow progression until the teenage years where the disease than progresses rapidly. Hypomyelination neuropathy is a neurological disorder present at birth characterized by respiratory difficulty, muscle weakness, and loss of coordination. Roussy-Levy syndrome is a neuromuscular disorder characterized by poor judgment of movement, absence of reflexes, and muscle atrophy.

 
Product Number Title Applications Host Clonality
AC15-0120 Anti-Apolipoprotein A I Antibody ELISA, WB, IHC, ICC, IF Goat Polyclonal
AC16-0010 Anti-GAPDH Antibody WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-01 Anti-GAPDH Antibody (AMCA) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-02 Anti-GAPDH Antibody (AP) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-03 Anti-GAPDH Antibody (APC) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-04 Anti-GAPDH Antibody (APC-Cy5.5) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-05 Anti-GAPDH Antibody (APC-Cy7) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-06 Anti-GAPDH Antibody (Avidin) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-07 Anti-GAPDH Antibody (Biotin) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-08 Anti-GAPDH Antibody (BPE) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-09 Anti-GAPDH Antibody (Cy3) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-10 Anti-GAPDH Antibody (Cy5) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)