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Neural Stem Cell Markers

Stem cells are undifferentiated cells that have the capability to differentiate into specialized cell types. Stem cells are found in embryos during the blastocyte phase and also in adult tissue. A blastocyte is a 4 or 5 day old embryo. These stem cells can be harvested from embryos produced during the in-vitro fertilization process which may not be implanted or used in assisted reproduction attempts. The harvesting of embryonic stem cells does destroy the embryo. Embryonic stem cells have the potential to become any cell in the body. Stem cells can also be harvested from umbilical cord blood during birth. These cells can be less malleable, but still useful in treating certain diseases, especially leukemias. The cord blood stem cells are picked out in a sea of other typical blood cells. Adult stem cells are found in organs that have the capability to renew or regenerate themselves. Adult stem cells, or somatic stem cells, are most commonly found in bone marrow, brain tissue, blood, skeletal muscles, skin, teeth, and testis. Once removed from the body, however, adult stem cells quickly lose their ability to differentiate. Neural stem cells are a type of stem cell characterized by their ability to differentiate into neurons and glial cells like astrocytes and oligodendrocytes. A biological marker is an indicator of a biological state. Often times it may be difficult to take biopsy or living tissue sample for medical diagnostics or scientific research purposes. Neuronal markers make it easier to look into the nervous system. Neuronal markers are present in the brain and peripheral nervous system and are indicative of certain neuronal diseases, statuses, or conditions. Neuronal markers are typically very effective diagnostic or prognostic tools in the treatment of sickness. These biomarkers can also be used to identify neural cells or detect expression details of certain types of molecules. Neural stem cell antibodies can bind to these biological markers. This is useful to detect the activity and expression of certain neural stem cells.

Anti-MSX1 antibody binds against the target msh homeobox 1 like protein. This protein is localized in the cell nucleus and expressed in the developing nail bed mesenchyme. MSH homeobox 1 like protein acts as a transcriptional repressor and plays a role in limb-pattern formation. Defects in MSX1 are the cause of tooth agenesis selective type 1, Witkop syndrome, and non-syndromic orofacial cleft type 5. Tooth agenesis selective type 1 is a form of selective tooth agenesis characterized by congential absence of one or more teeth. Witkop syndrome, or "tooth and nail syndrome", is a rare disorder characterized by weak, thin nails of small size along with the absence of certain teeth. Non-syndromic orofacial cleft type 5 is a common birth defect consisting of cleft lips with or without a cleft palate. Anti-PAX6 antibody binds against the target paired box 6. PAX6 is localized in the nucleus of developing eye and brain cells. PAX6 is a transcription factor implicated in the development of the eye, nose, CNS, and pancreas. Defects in PAX6 are the cause of aniridia, Peter's anomaly, foveal hypoplasia, and keratitis hereditary. Aniridia is the absence of an iris in the eye. As the iris is responsible for controlling the inlet of light, lacking the iris leads to severely compromised vision. The pupil stands wide open. Treatment includes using dark colored contact lenses to somewhat filter the amount of light hitting the retina. Peter's anomaly is a very rare disorder which causes corneal opacity which effectively decreases the ability to see to the point of near or complete blindness. Foveal hypoplasia is an hereditary ocular disease characterized by cataracts, ocular albinism, and iris anomalies. Keratitis is an inflammation of the eye's cornea causing intense pain and impaired sight.

 
Product Number Title Applications Host Clonality
AC16-0039 Anti-NeuroD1 Antibody IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-01 Anti-NeuroD1 Antibody (AMCA) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-02 Anti-NeuroD1 Antibody (AP) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-03 Anti-NeuroD1 Antibody (APC) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-04 Anti-NeuroD1 Antibody (APC-Cy5.5) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-05 Anti-NeuroD1 Antibody (APC-Cy7) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-06 Anti-NeuroD1 Antibody (Avidin) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-07 Anti-NeuroD1 Antibody (Biotin) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-08 Anti-NeuroD1 Antibody (BPE) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-09 Anti-NeuroD1 Antibody (Cy3) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-10 Anti-NeuroD1 Antibody (Cy5) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-11 Anti-NeuroD1 Antibody (Cy5.5) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)