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Motor Proteins

Motor proteins are protein molecules that move along the surface of a cell or substrate propelled by ATP fuel. These proteins are responsible for the majority of active protein transports using vesicles in the cytoplasm. Motor proteins are also the driving force behind muscle contraction. There are different types of motor proteins including actins, kinesins, microtubules, and mysosins. Myosin motors move along actin filaments to generate cell surface contractions. Although there are many different types of myosins, they all have heads that can bind and hydrolyze ATP for energy. Their tails differ depending on subtype. Kinesin and dynein based motors move vesicles and organelles within the cells and act upon flagella and cilia to provide movement during mitotic and meiotic spindle generation during chromosome replication. Kinesins consist of many different proteins. These motor proteins typically have two large heavy chain proteins and two small light chain proteins. During movement of kinesins, the tail portion can bind to the cargo and then alternate movement of the heads of the two heavy chains to propel forward. Dyneins also consist of multiple smaller proteins but have a more complicated structure compared to the kinesins. Dyneins essentially use their two tales or "legs" to move or "walk" along microtubules. Motor protein antibodies can bind against the motor proteins to inhibit, facilitate, or otherwise change the action of the motor protein.

Anti-MYO9B antibody binds against the target myosin IX. Myosin IX is localized in the cytoplasm, on membranes, and within the actin cytoskeleton. Myosin IX belongs to a family of unconventional myosins that differ from conventional myosins. There are several isoforms of myosin IX that are involved in signal transduction and leukocyte differentiation. Anti-KLF6 antibody binds against the target kruppel like factor 6. KLF6 is localized in the nucleus and highly expressed in placenta, spleen, thymus, prostate, testis, small intestine, and colon. Kruppel like factor 6 is a transcriptional activator that plays a role in B-cell growth and development. Defects in KLF6 are the cause of gastric cancer and prostate cancer. Gastric cancer is a type of cancer that starts in the gut. Symptoms include abdominal pain, dark stools, excessive gas, loss of appetite, nausea, weight loss, and weakness. Treatment can range but complete removal of the stomach is thought to provide a cure. Prostate cancer starts in the prostate gland. The prostate is a small structure that exists in the male reproductive system. One's chances for prostate cancer increase drastically with age as prostate cancer is the most common death among men over age 75. Affected individuals experience symptoms like delayed start of urine stream, urine leaking, blood in urine, and lower back or pelvis pain. Treatment includes surgery, radiation, and chemotherapy. For those with the prostate removed, their fertility is compromised and those individuals are typically sterile.

 
Product Number Title Applications Host Clonality
AC21-2965 Anti-MYO1H Antibody ELISA, WB Goat Polyclonal
AC21-0200-01 Anti-KIF4A Antibody (AMCA) ELISA, WB, IF Goat Polyclonal
AC21-0200-02 Anti-KIF4A Antibody (AP) ELISA, WB, IF Goat Polyclonal
AC21-0200-03 Anti-KIF4A Antibody (APC) ELISA, WB, IF Goat Polyclonal
AC21-0200-04 Anti-KIF4A Antibody (APC-Cy5.5) ELISA, WB, IF Goat Polyclonal
AC21-0200-05 Anti-KIF4A Antibody (APC-Cy7) ELISA, WB, IF Goat Polyclonal
AC21-0200-06 Anti-KIF4A Antibody (Avidin) ELISA, WB, IF Goat Polyclonal
AC21-0200-07 Anti-KIF4A Antibody (Biotin) ELISA, WB, IF Goat Polyclonal
AC21-0200-08 Anti-KIF4A Antibody (BPE) ELISA, WB, IF Goat Polyclonal
AC21-0200-09 Anti-KIF4A Antibody (Cy3) ELISA, WB, IF Goat Polyclonal
AC21-0200-10 Anti-KIF4A Antibody (Cy5) ELISA, WB, IF Goat Polyclonal
AC21-0200-11 Anti-KIF4A Antibody (Cy5.5) ELISA, WB, IF Goat Polyclonal