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Mitochondrial Metabolism

The mitochondrion is a membrane enclosed organelle which processes much of the cellular energy. MItrochondria are found in most eukaryotic cells. In addition to providing cellular energy, the mitochondria are also involved in cell signaling, cell differentiation, apoptosis, cell growth, and cell cycle control. Mitochondria have their own unique DNA sequences which are different from the organism as a whole and very similar to bacterial genomes. Mitochondria metabolize a number of molecules in the process of producing energy for cellular use. Energy metabolism is the process by which the calories in the fats, sugars, and proteins consumed are converted into ATP. The mitochondria can then convert that ATP into ADP, releasing energy in the process of mitochondrial metabolism.

Anti-CPT1A antibody binds against the target protein carnitine palmitoyltransferase 1A. CPT1A is localized on the mitochondrion outer membrane and expressed in the kidney, heart, liver, and skeletal muscle. CPT1A is involved in lipid metabolism and fatty acid beta-oxidation. Defects in CPT1A are the cause of carnitine palmitoyltransferase 1A deficiency. Individuals with carnitine palmitoyltransferase 1A deficiency can suffer sudden liver failure with stress or injury to the nervous system, illness, or fasting. The disorder is a dysfunction of long-chain fatty acid oxidation. Anti-SOD2 antibody binds against the target superoxide dismutase mitochondrial precursor. SOD2 is localized on the matrix of the mitochondria. SOD2 destroys superoxide anion radicals produced within the cells that are toxic to the cells. Defects in SOD2 are associated with micro-vascular complications of diabetes type 6. This condition is pathological and develops in many different tissues and organs. Symptoms include retinopathy, nephropathy leading to renal disease, and neuropathy.

 
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Product Number Title Applications Host Clonality
AC14-0041-13 Anti-Cytochrome P450 1A2 Antibody (Glucose Oxidase) ELISA, WB, IHC, ICC, IF Mouse Monoclonal (D15)