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Microtubules

Microtubules are components of the cell's cytoskeleton. The cytoskeleton proteins form the scaffolding of a cell and effectively give it structure to hold the cell contents inside. Microtubules are the largest of the cytoskeleton filaments, being larger than both actin filaments and intermediate filaments. Microtubules function as motor proteins. Motor proteins are protein molecules that move along the surface of a cell or substrate propelled by ATP fuel. These proteins are responsible for the majority of active protein transports using vesicles in the cytoplasm. They are also the driving force behind muscle contraction. Microtubules are also implicated in mitosis and other cellular processes. They are composed of polymerized alpha and beta tubulin dimers arranged end to end forming a protofilament. Thirteen of these protofilaments come together side by side and rolled up into a cylinder to form one microtubule.

Anti-Kinesin 5A antibody binds against the target kinesin 5A. KIF5A is localized in the perinuclear region of the cytoplasm and in the cytoskeleton. Kinesin 5A is a microtubule dependent moto required for slow axonal transport of neurofilament proteins. Defects in KIF5A are the cause of spastic paraplegia autosomal dominant type 10. Hereditary spastic paraplegia is a disease characterized by progressive stiffness and contraction (spasticity) of the lower limbs. Affected individuals experience progressive difficulty walking (trouble with balance and stumbling) that starts between 20 and 40 years of age. As hereditary spastic paraplegia progresses, individuals experience urinary urgency, hyperactive reflexes, muscle spasms, and congenital foot defects. There are no treatments available to cure the disorder, but there are medications that can help decrease symptom severity and help reduce spasticity. Therapy is centered on maintaining flexibility, strength, and range of motion. Supplemental devices are also used to help with movement as well as communication is patients where the disorder has progressed.

 
Product Number Title Applications Host Clonality
AC21-2708 Anti-Doublecortin Antibody ELISA, WB Goat Polyclonal
AC21-2728 Anti-Beta III Tubulin Antibody ELISA, WB Goat Polyclonal
AC21-0159-01 Anti-MARK4 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0159-02 Anti-MARK4 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0159-03 Anti-MARK4 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0159-04 Anti-MARK4 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0159-05 Anti-MARK4 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0159-06 Anti-MARK4 Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0159-07 Anti-MARK4 Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0159-08 Anti-MARK4 Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0159-09 Anti-MARK4 Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0159-10 Anti-MARK4 Antibody (Cy5) ELISA, WB Goat Polyclonal