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Methylation

Chromatin is the structure formed between DNA and proteins assembled in the cell's nucleus. The nucleosome, the basic unit of chromatin, is highly condensed making the individual genetic material or genes on the DNA hidden or inaccessible by certain biological molecules. The DNA is wound around histone proteins. Chromatin modification involves enzymes that affect DNA transcription. Chromatin modifying enzymes essentially work to make the condensed chromatin accessible for transcription factors, DNA replication, recombination, and repair. There are many different surfaces to nucleosomes which provide many different binding sites for chromatin modifying enzymes. There are at least eight different classes of modifiers which have been characterized based on site and mechanism of action. These chromatin modifying enzymes have the potential to influence many fundamental biological processes of which some may be epigenetically inherited. DNA methylation is the addition of a methyl (CH3) group to a cytosine base residue in DNA. This process occurs during normal development and cellular differentiation. This process is carried out by enzymes called DNA methyltransferases (in mammals) and typically leads to the suppression of the gene to which the methyl group has been added. By this mechanism, DMA methylation is one of the methods that can be used to regulate the expression of genes.

Anti-PADI4 / PAD4 antibody binds against the target peptidyl arginine deiminase type IV. PADI4 is localized in the cytoplasm and nucleus. It is expressed in eosinophils and neutrophils. PADI4 catalyzes the deamination of arginine residues in proteins. Defects in PADI4 are a cause of susceptibility to rheumatoid arthritis. Rheumatoid arthritis is a long-term autoimmune disorder that leads to inflammation of joints and surrounding tissues. Symptoms of RA include joint pain, morning stiffness of joints, chest pain, nodules under skin, and sleep difficulties. Anti-ERG antibody binds against the target ERG. ERG is localized in the nucleus and cytoplasm and acts as a transcriptional regulator. Defects in ERG are the cause of Ewing sarcoma. Ewing sarcoma is a rare form of cancer that can be found in bone or soft tissue of many different areas of the body. It typically affects children. Ewing tumors are small, round, and blue cell. Symptoms include soreness at the tumor site, swelling, and warmth. Treatment includes chemotherapy and radiation along with surgery to remove any tumors.

 
Product Number Title Applications Host Clonality
AC21-2682 Anti-PRDM16 Antibody ELISA, WB Goat Polyclonal
AC21-2683 Anti-PRMT3 Antibody ELISA, WB Goat Polyclonal
AC21-2684 Anti-PRMT2 Antibody ELISA, WB Goat Polyclonal
AC21-2685 Anti-PRMT6 Antibody ELISA, WB Goat Polyclonal
AC21-2686 Anti-PRMT7 Antibody ELISA, WB Goat Polyclonal
AC21-0034-01 Anti-MTR Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0034-02 Anti-MTR Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0034-03 Anti-MTR Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0034-04 Anti-MTR Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0034-05 Anti-MTR Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0034-06 Anti-MTR Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0034-07 Anti-MTR Antibody (Biotin) ELISA, WB Goat Polyclonal