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Metabolic Disease Antibodies

Metabolism is the biochemical process by which an organism converts what it ingests into energy. This energy is used for many biological processes like thinking, growing, breathing, and pumping blood to all the organs in the body. Metabolism is a constant process as metabolic reactions are concurrently occurring in the body and cells at the same time, all the time. The endocrine system plays a very important role in metabolism. Many glands and hormones of the endocrine system are involved in controlling the rate and direction of metabolism. The thyroid and the pancreas, most importantly, help to produce hormones like thyroxine and insulin to control a body’s metabolism. Each person has a different basal metabolic rate. Metabolic diseases or metabolic disorders are a group of diseases that are caused by abnormal chemical reactions in the body’s cells. The organs can malfunction in their production of certain metabolic enzymes or hormones or the enzymes or hormones themselves can fail to function properly. Examples of metabolic disorders include galactosemia, diabetes, hyperthyroidism, hypothyroidism, and phenylketonuria. Metabolic disease antibodies are useful in many aspects of biochemical research.

Anti-adipose triglyceride lipase antibody binds against the target adipose triglyceride lipase. Adipose triglyceride lipase is an enzyme that catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte liquids. ATGL is localized in the liquid droplets and in cell membranes. It is most highly expressed in fat tissue however it is also detected in the heart, skeletal muscle, and digestive tract. Defects in ATGL are associated with diabetes mellitus type 2. Type 2 diabetes is a form of diabetes mellitus that occurs in overweight adults who have a resistance to insulin. Anti-FTO antibody binds against the target FTO. FTO is a dioxygenase that repairs RNA and DNA by oxidative demethlyation. FTO is expressed in many tissues and very highly expressed in adrenal glands, the brain, the hypothalamus, and the pituitary gland. FTO contributes to the regulation of the global metabolic rate, energy expenditure, and energy homeostasis. FTO also contributes to the regulation of body size and body fat accumulation. Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GFDDCFED). Growth retardation developmental delay coarse facies and early death is a rare syndrome characterized course facial features with anteverted nostrils, thin vermilion, prominent alveolar ridge, and a protruding tongue. Affected individuals suffer from intrauterine growth retardation and heart defects including ventricular septal defects, atrioventricular defects, and patent arteriousus with or without cardiomyopathy. Individuals with growth retardation developmental delay course facies and early death will usually die by the age of 3 years.

 
Product Number Title Applications Host Clonality
AC16-0049 Anti-FTO Antibody WB, IHC(F), ICC, IF, FC Rabbit Polyclonal
AC21-2669 Anti-ABCD2 Antibody ELISA, WB Goat Polyclonal
AC21-2691 Anti-Estrogen Receptor Beta Antibody ELISA, WB Goat Polyclonal
AC21-2694 Anti-SLC25A38 Antibody ELISA Goat Polyclonal
AC21-2697 Anti-DAGK Antibody ELISA Goat Polyclonal
AC21-2700 Anti-Synaptotagmin VI Antibody ELISA Goat Polyclonal
AC21-2702 Anti-MAT2B Antibody ELISA, WB Goat Polyclonal
AC21-2703 Anti-Synaptotagmin V Antibody ELISA, WB Goat Polyclonal
AC21-2712 Anti-Apolipoprotein J Antibody ELISA, WB Goat Polyclonal
AC21-2721 Anti-Gluthathione Peroxidase 1 Antibody ELISA, WB Goat Polyclonal
AC21-2722 Anti-Gluthathione Peroxidase 1 Antibody ELISA, WB Goat Polyclonal
AC21-2723 Anti-Caspase 12 Antibody ELISA, WB Goat Polyclonal