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Mesoderm Markers

The mesoderm is one of the three developing germ layers of an animal embryo. The mesoderm is the middle layer of the embryo that eventually goes on to develop into the mesenchymal or connective tissue, non-epithelial blood cells, cardiac muscle, skeletal muscle, tubule cells of the kidney, and immune cells called coelomocytes. Mesodermal lineage markers are used to study the endodermal cells and determine which cells go where when forming the organs and tissues. These markers assist in mapping the stages of the mesoderm differentiation during development. Interestingly enough, the stages of early development have been recapitulated in vitro using embryonic stem cells.

Anti-alpha smooth muscle actin antibody binds against the target alpha smooth muscle actin. Actins are globular proteins that are the main framework of the thin filaments of muscle fibers. Actins are highly conserved proteins that are involved in many types of cell mobility. Alpha smooth muscle actin is an isoform of the typical smooth muscle cells. This actin is localized in the cytoplasm and the cytoskeleton. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6. Familial thoracic aortic aneurysm is an autosomal dominant form of large arterial disorder. The disease presents with a progressive breakdown of collagen, elastin, and smooth muscle in the wall of an artery, specifically the aorta. This caused the thoracic aorta to permanently dilate. Anti-NIR1 antibody binds against NIR1 (membrane-associated 3 protein). NIR1 catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes and binds calcium ions. NIR1 is localized in the endomembrane system and detected in the brain, spleen, and ovary. Defects in NIR1 are the cause of cone-rod dystrophy. Cone-rod dystrophy is a progressive, inherited disease that causes deterioration of the cones and rods in the eye. This deterioration typically results in loss of color vision, visual acuity, peripheral vision, and night vision. CRDs are characterized by pigment deposits on the retina that are visible upon examination and can lead to complete loss of vision.

 
Product Number Title Applications Host Clonality
AC21-2725 Anti-CD34 Antibody ELISA Goat Polyclonal
AC21-0584-01 Anti-alpha Smooth Muscle Actin Antibody (AMCA) ELISA, WB, IHC Goat Polyclonal
AC21-0584-02 Anti-alpha Smooth Muscle Actin Antibody (AP) ELISA, WB, IHC Goat Polyclonal
AC21-0584-03 Anti-alpha Smooth Muscle Actin Antibody (APC) ELISA, WB, IHC Goat Polyclonal
AC21-0584-04 Anti-alpha Smooth Muscle Actin Antibody (APC-Cy5.5) ELISA, WB, IHC Goat Polyclonal
AC21-0584-05 Anti-alpha Smooth Muscle Actin Antibody (APC-Cy7) ELISA, WB, IHC Goat Polyclonal
AC21-0584-06 Anti-alpha Smooth Muscle Actin Antibody (Avidin) ELISA, WB, IHC Goat Polyclonal
AC21-0584-07 Anti-alpha Smooth Muscle Actin Antibody (Biotin) ELISA, WB, IHC Goat Polyclonal
AC21-0584-08 Anti-alpha Smooth Muscle Actin Antibody (BPE) ELISA, WB, IHC Goat Polyclonal
AC21-0584-09 Anti-alpha Smooth Muscle Actin Antibody (Cy3) ELISA, WB, IHC Goat Polyclonal
AC21-0584-10 Anti-alpha Smooth Muscle Actin Antibody (Cy5) ELISA, WB, IHC Goat Polyclonal
AC21-0584-11 Anti-alpha Smooth Muscle Actin Antibody (Cy5.5) ELISA, WB, IHC Goat Polyclonal