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Lipid Signaling

Lipid is a general term for a group of molecules including fats, waxes, phospholipids, and glycerides. They are mainly responsible for energy storage, structural stability of cells, and signaling between cells. Lipids are hydrophobic molecules which mean they are not water soluble, are non-polar, and repel water. They are, however, soluble in organic solvents such as acetone and ether as well as in other lipids or fats. Although there are different types of lipids, they are mostly composed of carbon backbones or hydrocarbon chains with extra components depending on what type of lipid they are. Fats are composed of 3 fatty acids and a glycerol molecule. Phospholipids are composed of 2 fatty acids, a glycerol, and a phosphate. Steroids and waxes are ring like structures with a carbon skeleton. Lipid signaling events involve lipid messengers which can bind to receptors and mediate certain processes. The key lipid signalers are diacylglycerol (DAG), ceramides, platelet activating factor (PAF), and arachidonic acid.

Anti-FLAP antibody binds against FLAP target. Five lipoxygenase activating protein (ALOX5) is required for leukotriene biosynthesis and plays an essential role in transfer of arachidonic acid to ALOX5. FLAP belongs to the MAPEG family and is localized on the nucleus membrane and endoplasmic reticulum membrane. Defects in ALOX5AP may cause a susceptibility to ischemic stroke and myocardial infarction. Ischemic strokes are caused by clots inside the arteries in the brain. A myocardial infarction is also known as a heart attack and occurs when the blood flow to any part of the heart is obstructed and the heart muscle suffers by weakening or dying. Anti-SHIP antibody binds against signaling inositol polyphosphate 5' phosphatase. Ptdlns phosphatase is specifically expressed in immune and hematopoietic cells like bone marrow and blood cells. SHIP acts as a negative regulator of B-cell antigen receptor signaling.

 
Product Number Title Applications Host Clonality
AC16-0042 Anti-EDG1 Antibody WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-01 Anti-EDG1 Antibody (AMCA) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-02 Anti-EDG1 Antibody (AP) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-03 Anti-EDG1 Antibody (APC) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-04 Anti-EDG1 Antibody (APC-Cy5.5) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-05 Anti-EDG1 Antibody (APC-Cy7) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-06 Anti-EDG1 Antibody (Avidin) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-07 Anti-EDG1 Antibody (Biotin) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-08 Anti-EDG1 Antibody (BPE) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-09 Anti-EDG1 Antibody (Cy3) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-10 Anti-EDG1 Antibody (Cy5) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-11 Anti-EDG1 Antibody (Cy5.5) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)