Questions? Feedback? powered by Olark live chat software

Lipid Metabolism

Lipid is a general term for a group of molecules including fats, waxes, phospholipids, and glycerides. They are mainly responsible for energy storage, structural stability of cells, and signaling between cells. Lipids are hydrophobic molecules which mean they are not water soluble, are non-polar, and repel water. They are, however, soluble in organic solvents such as acetone and ether as well as in other lipids or fats. Although there are different types of lipids, they are mostly composed of carbon backbones or hydrocarbon chains with extra components depending on what type of lipid they are. Fats are composed of 3 fatty acids and a glycerol molecule. Phospholipids are composed of 2 fatty acids, a glycerol, and a phosphate. Steroids and waxes are ring like structures with a carbon skeleton. Lipid antibodies can react against proteins or molecules that bind to lipid type particles. There are relatively few antibodies that have the affinity to bind against lipids. However, there is more and more evidence for the presence of these anti-lipid antibodies in individuals with HIV infections and autoimmune brain inflammation such as multiple sclerosis.

The anti-quaking antibody binds against an RNA-binding protein that actively participates in myelination. The regulator of the myelination for the specific cell in the brain affected may show importance in the mental disorder schizophrenia. Antiphospholipid syndrome (APS) is an autoimmune disorder caused by such antibodies against cell- membrane phospholipids. It facilitates unnecessary blood clots and pregnancy related complications such as spontaneous abortion and fetal loss. Individuals affected with APS characteristically exhibit extraordinarily high amounts of antibodies that bind against membrane anionic (negatively charged) phospholipids or their plasma proteins. Anti-ARH antibody binds against the target ARH. ARH is localized in the cytoplasm and expressed in the kidney, liver, placenta, brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes. ARH is an adapter protein that is required for efficient endocytosis of the LDL receptor in hepatocytes and lymphocytes. Defects in ARH are the cause of autosomal recessive hypercholesterolemia. Autosomal recessive hypercholesterolemia is a rare disorder that is caused by a complete loss of function of the ARH adapter protein. This protein is required for the uptake of LDL (the “bad” cholesterol). ARH is characterized by increased cholesterol levels in the blood, deposition of cholesterol in the skin and tendons, and premature coronary artery disease.

 
Product Number Title Applications Host Clonality
AC15-0120 Anti-Apolipoprotein A I Antibody ELISA, WB, IHC, ICC, IF Goat Polyclonal
AC16-0011 Anti-P4HB Antibody WB Mouse Monoclonal (3-2B12)
AC16-0014 Anti-P4HB Antibody ELISA, WB, IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (6-9H6)
AC16-0049 Anti-FTO Antibody WB, IHC(F), ICC, IF, FC Rabbit Polyclonal
AC16-0050 Anti-LOX 1 Antibody WB, IHC(F), ICC, IF, FC Rabbit Polyclonal
AC16-0051 Anti-LOX 1 Antibody WB, IHC(F), IHC(P), ICC, IF, FC Rabbit Polyclonal
AC16-0062 Anti-ADFP Antibody WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0011-01 Anti-P4HB Antibody (AMCA) WB Mouse Monoclonal (3-2B12)
AC16-0011-02 Anti-P4HB Antibody (AP) WB Mouse Monoclonal (3-2B12)
AC16-0011-03 Anti-P4HB Antibody (APC) WB Mouse Monoclonal (3-2B12)
AC16-0011-04 Anti-P4HB Antibody (APC-Cy5.5) WB Mouse Monoclonal (3-2B12)
AC16-0011-05 Anti-P4HB Antibody (APC-Cy7) WB Mouse Monoclonal (3-2B12)