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Lineage Markers

Lineage marker antibodies are a group of antibodies that can bind against certain proteins in a sample. This can separate these proteins in a mixed sample and can be useful in many areas including forensic and genetic testing. These antibodies can bind against lineage markers. These markers are present in different samples which can be compared to each other and used to determine the lineage of certain inherited traits. For example, a marker studied in a gene that expresses a phenotype seen only in all male offspring can be deciphered as marking a gene that is passed completely on in only the Y chromosome. This marker can be traced back along the lineage, and lineage marker antibodies can be used to determine which chromosomes contain the marker.

Anti-alpha smooth muscle actin antibody binds against the target alpha smooth muscle actin. Actins are globular proteins that are the main framework of the thin filaments of muscle fibers. Actins are highly conserved proteins that are involved in many types of cell mobility. Alpha smooth muscle actin is an isoform of the typical smooth muscle cells. This actin is localized in the cytoplasm and the cytoskeleton. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6. Familial thoracic aortic aneurysm is an autosomal dominant form of large arterial disorder. The disease presents with a progressive breakdown of collagen, elastin, and smooth muscle in the wall of an artery, specifically the aorta. This caused the thoracic aorta to permanently dilate. Anti-PAX6 antibody binds against the target paired box 6. PAX6 is localized in the nucleus of developing eye and brain cells. PAX6 is a transcription factor implicated in the development of the eye, nose, CNS, and pancreas. Defects in PAX6 are the cause of aniridia, Peter's anomaly, foveal hypoplasia, and keratitis hereditary. Aniridia is the absence of an iris in the eye. As the iris is responsible for controlling the inlet of light, lacking the iris leads to severely compromised vision. The pupil stands wide open. Treatment includes using dark colored contact lenses to somewhat filter the amount of light hitting the retina. Peter's anomaly is a very rare disorder which causes corneal opacity which effectively decreases the ability to see to the point of near or complete blindness. Foveal hypoplasia is an hereditary ocular disease characterized by cataracts, ocular albinism, and iris anomalies. Keratitis is an inflammation of the eye's cornea causing intense pain and impaired sight.

 
Product Number Title Applications Host Clonality
AC21-2642 Anti-PAX3 Antibody ELISA, WB Goat Polyclonal
AC21-2725 Anti-CD34 Antibody ELISA Goat Polyclonal
AC21-2805 Anti-Stra6 Antibody ELISA, WB Goat Polyclonal
AC21-2815 Anti-SOX10 Antibody ELISA, WB Goat Polyclonal
AC21-2885 Anti-Stra6 Antibody ELISA Goat Polyclonal
AC21-0234-01 Anti-GATA3 Antibody (AMCA) ELISA, WB, IHC Goat Polyclonal
AC21-0234-02 Anti-GATA3 Antibody (AP) ELISA, WB, IHC Goat Polyclonal
AC21-0234-03 Anti-GATA3 Antibody (APC) ELISA, WB, IHC Goat Polyclonal
AC21-0234-04 Anti-GATA3 Antibody (APC-Cy5.5) ELISA, WB, IHC Goat Polyclonal
AC21-0234-05 Anti-GATA3 Antibody (APC-Cy7) ELISA, WB, IHC Goat Polyclonal
AC21-0234-06 Anti-GATA3 Antibody (Avidin) ELISA, WB, IHC Goat Polyclonal
AC21-0234-07 Anti-GATA3 Antibody (Biotin) ELISA, WB, IHC Goat Polyclonal