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Lineage Determination

Lineage determination, or cell fate determination, is the process by which the final cell type or fate of a particular immature cell can be deciphered. During embryogenesis in animals, the germ layers develop embryonic stem cells which will later become all of the parts of the body. Each cell in an embryo receives and sends cues with the surrounding cells and retains a memory of its own movement and development. There are a few modes of lineage determination including autonomous specification, conditional specification, and syncytial specification.

Anti-pax3 antibody binds against the target pax3 (paired box protein 3). Pax3 functions as a transcription factor associated with the development of alveolar rhabdomyosarcoma. Paired box protein 3 is localized in the cell nucleus. Defects in PAX3 are the cause of Waardenburg syndrome, craniofacial-deafness-hand syndrome, and rhabdomyosarcoma. Waardenburg syndrome is a genetic syndrome with a variety of related defects. Waardenburg syndrome is characterized by partial albinism, wide set eyes, and deafness. Craniofacial-deafness-hand syndrome is characterized by distinctive facial features, hearing loss, and hand abnormalities. Affected individuals have a flat facial profile, slit like nostrils, and loss of hearing. Rhabdomyosarcoma is a cancerous tumor that is attached to the bone inside of the muscle. Rhabdomyosarcoma is a rare form of cancer treated with radiation or chemotherapy or a combination of both. Anti-alpha smooth muscle actin antibody binds against the target alpha smooth muscle actin. Actins are globular proteins that are the main framework of the thin filaments of muscle fibers. Actins are highly conserved proteins that are involved in many types of cell mobility. Alpha smooth muscle actin is an isoform of the typical smooth muscle cells. This actin is localized in the cytoplasm and the cytoskeleton. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6. Familial thoracic aortic aneurysm is an autosomal dominant form of large arterial disorder. The disease presents with a progressive breakdown of collagen, elastin, and smooth muscle in the wall of an artery, specifically the aorta. This caused the thoracic aorta to permanently dilate.

 
Product Number Title Applications Host Clonality
AC21-2642 Anti-PAX3 Antibody ELISA, WB Goat Polyclonal
AC21-2725 Anti-CD34 Antibody ELISA Goat Polyclonal
AC21-2805 Anti-Stra6 Antibody ELISA, WB Goat Polyclonal
AC21-2815 Anti-SOX10 Antibody ELISA, WB Goat Polyclonal
AC21-2885 Anti-Stra6 Antibody ELISA Goat Polyclonal
AC21-0234-01 Anti-GATA3 Antibody (AMCA) ELISA, WB, IHC Goat Polyclonal
AC21-0234-02 Anti-GATA3 Antibody (AP) ELISA, WB, IHC Goat Polyclonal
AC21-0234-03 Anti-GATA3 Antibody (APC) ELISA, WB, IHC Goat Polyclonal
AC21-0234-04 Anti-GATA3 Antibody (APC-Cy5.5) ELISA, WB, IHC Goat Polyclonal
AC21-0234-05 Anti-GATA3 Antibody (APC-Cy7) ELISA, WB, IHC Goat Polyclonal
AC21-0234-06 Anti-GATA3 Antibody (Avidin) ELISA, WB, IHC Goat Polyclonal
AC21-0234-07 Anti-GATA3 Antibody (Biotin) ELISA, WB, IHC Goat Polyclonal