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Krueppel-like Factors

Protein families, or protein domain families, are groups of protein domains that are related somehow, usually by gene families or evolutionary parameters. Proteins within a family have common ancestors from which they descend. This gives proteins within the same domain family similar three-dimensional structures, functions, and sequence similarities. Between 40 and 65% of proteins known will show sequence similarity to other proteins. When sequence similarity is known, structural and functional similarity is assumed. Kruppel-like factors, or KLFs, are classified together in a protein domain family and play major roles in cell proliferation, differentiation, survival, and cancer.

Anti-EKLF/ KLF1 antibody binds against the target erythroid kruppel like factor. EKLF is localized in the cell nucleus and expressed in adult bone marrow cells and fetal liver cells. EKLF is a transcription regulator of erythrocyte development that serves as a switch factor during srythropoiesis. Defects in KLF1 are the cause of congenital dyserythropoietic anemia type 4. Congenital dyserythropoietic anemia is a rare blood disorder characterized by the premature death of red blood cells and a decreased output of red blood cells from the bone marrow. Anti-KLF6 antibody binds against the target kruppel like factor 6. KLF6 is localized in the nucleus and highly expressed in placenta, spleen, thymus, prostate, testis, small intestine, and colon. Kruppel like factor 6 is a transcriptional activator that plays a role in B-cell growth and development. Defects in KLF6 are the cause of gastric cancer and prostate cancer. Gastric cancer is a type of cancer that starts in the gut. Symptoms include abdominal pain, dark stools, excessive gas, loss of appetite, nausea, weight loss, and weakness. Treatment can range but complete removal of the stomach is thought to provide a cure. Prostate cancer starts in the prostate gland. The prostate is a small structure that exists in the male reproductive system. One's chances for prostate cancer increase drastically with age as prostate cancer is the most common death among men over age 75. Affected individuals experience symptoms like delayed start of urine stream, urine leaking, blood in urine, and lower back or pelvis pain. Treatment includes surgery, radiation, and chemotherapy. For those with the prostate removed, their fertility is compromised and those individuals are typically sterile.

 
Product Number Title Applications Host Clonality
AC16-0045 Anti-KLF4 Antibody ELISA, WB Rabbit Polyclonal
AC16-0045-01 Anti-KLF4 Antibody (AMCA) ELISA, WB Rabbit Polyclonal
AC16-0045-02 Anti-KLF4 Antibody (AP) ELISA, WB Rabbit Polyclonal
AC16-0045-03 Anti-KLF4 Antibody (APC) ELISA, WB Rabbit Polyclonal
AC16-0045-04 Anti-KLF4 Antibody (APC-Cy5.5) ELISA, WB Rabbit Polyclonal
AC16-0045-05 Anti-KLF4 Antibody (APC-Cy7) ELISA, WB Rabbit Polyclonal
AC16-0045-06 Anti-KLF4 Antibody (Avidin) ELISA, WB Rabbit Polyclonal
AC16-0045-07 Anti-KLF4 Antibody (Biotin) ELISA, WB Rabbit Polyclonal
AC16-0045-08 Anti-KLF4 Antibody (BPE) ELISA, WB Rabbit Polyclonal
AC16-0045-09 Anti-KLF4 Antibody (Cy3) ELISA, WB Rabbit Polyclonal
AC16-0045-10 Anti-KLF4 Antibody (Cy5) ELISA, WB Rabbit Polyclonal
AC16-0045-11 Anti-KLF4 Antibody (Cy5.5) ELISA, WB Rabbit Polyclonal