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Intracellular Signaling

Intracellular signaling involves signal transduction with certain molecules (peptides and proteins) found inside a cell that serve to transmit extracellular signals to intracellular effectors. Signal transduction refers to the process of signaling between cells or other molecules in the cellular environment that occurs when a surface cell receptor is activated by a molecule, such as an antibody, creating a response. The resulting action then mediates a reaction within the cell through a second messenger which elicits the physiological response. Simplified, the process involves a binding of a ligand on the surface of a cell to a receptor, like a G protein coupled receptor. This transmits a signal into the cell which can act immediately or activate other cellular molecules. This protein undergoes certain changes and is essentially activated, released by the receptor, and able to bind to distant binding sites.

Anti-CAPON antibody binds against the adapter protein nitric oxide synthase 1. CAPON is involved in neuronal nitric-oxide synthesis regulation. CAPON mediates an indirect interaction between NOS1 and RASD11 leading to the enhanced ability of NOS1 to activate RASD1. Anti-MERTK antibody binds against the target MERTK. MERTK is localized on the cell membrane and expressed in numerous neoplastic B- and T-cell lines (but not expressed in normal B- and T-lymphocytes). Defects in MERTK are the cause of retinitis pigmentosa type 38. Retinitis pigmentosa is an autosomal dominant disorder characterized by a progressive loss of photoreceptors in the retina. Affected individuals suffer from night blindness, tunnel vision, blurry vision, and extreme tiredness. Retinitis pigmentosa is a degenerative disorder that continually worsens as the individual grows older. Those affected appear physically normal.

 
Product Number Title Applications Host Clonality
AC21-2950 Anti-Netrin G1 Antibody ELISA Goat Polyclonal
AC21-0058-01 Anti-TRPM7 Antibody (AMCA) ELISA, IHC Goat Polyclonal
AC21-0058-02 Anti-TRPM7 Antibody (AP) ELISA, IHC Goat Polyclonal
AC21-0058-03 Anti-TRPM7 Antibody (APC) ELISA, IHC Goat Polyclonal
AC21-0058-04 Anti-TRPM7 Antibody (APC-Cy5.5) ELISA, IHC Goat Polyclonal
AC21-0058-05 Anti-TRPM7 Antibody (APC-Cy7) ELISA, IHC Goat Polyclonal
AC21-0058-06 Anti-TRPM7 Antibody (Avidin) ELISA, IHC Goat Polyclonal
AC21-0058-07 Anti-TRPM7 Antibody (Biotin) ELISA, IHC Goat Polyclonal
AC21-0058-08 Anti-TRPM7 Antibody (BPE) ELISA, IHC Goat Polyclonal
AC21-0058-09 Anti-TRPM7 Antibody (Cy3) ELISA, IHC Goat Polyclonal
AC21-0058-10 Anti-TRPM7 Antibody (Cy5) ELISA, IHC Goat Polyclonal
AC21-0058-11 Anti-TRPM7 Antibody (Cy5.5) ELISA, IHC Goat Polyclonal