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Intracellular Apoptosis Signals

Apoptosis is the process by which cells die a programmed death or PCD. The process is facilitated by processes within the cell using certain biochemicals that lead to changes in cell morphology and eventually leads to the cell dying. This is a natural process in the cell cycle and is necessary to maintain proper alignments of organ and organelle structure. Defects in the apoptosis of cells can lead to diseases such as cancer. Each cell must die in order to make room for fresh replacements. Apoptosis can also be useful in the breakdown of cells into their parts for recycling and re-use. It is essentially induction of cell suicide. Apoptosis can be triggered by internal or external signals. Externally, apoptosis receptors can activate intracellular kinases. These intracellular kinases can ultimately activate or inhibit proteins involved in apoptosis or even affect transcription factors. These apoptotic transcription factors can inhibit the expression of pro-apoptotic proteins or promote the expression of cell survival proteins.

Anti-MEK antibody binds against MEK antigen. MEK is widely expressed throughout the body. MAPKK activates certain kinases like ERK1, ERK2, and MAP. Defects in MAPKK (MEK) are the cause of cardiofaciocutaneous syndrome. Cardiofaciocutaneous syndrome is a multi-system disorder that primarily affects the heart, facial features, skin, and hair. Cardiofaciocutaneous syndrome is characterized by heart defects, distinctive facial features, and skin abnormalities. Those with cardiofaciocutaneous syndrome typically have high narrowed foreheads, short noses, widely spaced eyes, droopy eyelids, a small chin, and low-set ears. Anti-Bcl-2 antibody binds against bcl-2. Bcl-2 suppresses apoptosis in many different cells and tissues. Bcl2 is located on the mitochondrion outer membrane, the nuclear membrane, and the endoplasmic reticulum membrane. Defects in BCL2 are thought to cause lymphatic leukemia, non-Hodgkin lymphoma, and other types of cancers. Lymphatic leukemia is a progressive malignant disease of the blood forming tissues and organs including the bone marrow. The disease is characterized by distorted production and development of leukocytes and their precursors in the bone marrow and circulating blood.

 
Product Number Title Applications Host Clonality
AC16-0036 Anti-SOX17 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0045 Anti-KLF4 Antibody ELISA, WB Rabbit Polyclonal
AC16-0046 Anti-Oct4 Antibody WB Rabbit Polyclonal
AC16-0047 Anti-p53 Antibody ELISA, WB, IHC(F), IHC(P) Rabbit Polyclonal
AC16-0036-01 Anti-SOX17 Antibody (AMCA) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-02 Anti-SOX17 Antibody (AP) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-03 Anti-SOX17 Antibody (APC) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-04 Anti-SOX17 Antibody (APC-Cy5.5) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-05 Anti-SOX17 Antibody (APC-Cy7) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-06 Anti-SOX17 Antibody (Avidin) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-07 Anti-SOX17 Antibody (Biotin) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-08 Anti-SOX17 Antibody (BPE) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
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