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Interleukins

Interleukins are essentially cytokines. Cytokines are cell signaling molecules composed of protein that are secreted by many different bodily cells. The cytokines can interact with the cells of the immune system in order to regulate the body's response to disease and infection. They also regulate various inflammatory responses. There are many different types of cytokines including colony stimulating factors, growth and differentiation factors, and immunoregulatory and proinflammatory cytokines. Interleukins are cytokines that are produced by lymphoid and non-lymphoid cells (mainly T cells and phagocytes) and can stimulate, regulate, or modulate lymphocytes. Interleukins are typically referred to by number, for example: IL-1, IL-2, etc. Each type, or class, has a particular function. These functions include stimulating T-cells, growing blood cell precursors, promoting growth of mast cells, and chemo-attracting T cells. Basically, interleukins regulate immune responses. Some interleukins are used in cancer treatment to boost the patient's immune system.

Anti-IRAK4 Antibody binds against interleukin 1 receptor associated kinase 4. IRAK4 triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization and phosphorylates IRAK1. Defects in IRAK4 cause recurrent isolated invasive pneumococcal disease type 1 and IRAK4 deficiency. Recurrent isolated invasive pneumococcal disease type 1 occurs when the individual has two episodes of IPD occurring at least one month apart. IPD, or invasive pneumococcal disease, is an infection caused by streptococcus pneumonia which results in pneumonia, sepsis, ear infection, and bacterial meningitis. IRAK4 deficiency is very rare inherited disorder of the immune system which leads to recurrent infections by pyogenic (puss producing) bacteria. Anti-B7H4 antibody binds against the target protein B7H4. B7H4 inhibits T-cell activation, proliferation, and development. By doing this, it negatively regulates the T-cell mediated immune response. B7H4 is localized on the cell membrane and expressed at the cell surface. The protein is overexpressed in breast, ovarian, endometrial, renal cell, and non-small-cell lung cancers. B7H4 is also expressed on activated T and B cells but not expressed in normal tissues.

 
Product Number Title Applications Host Clonality
AC16-0034 Anti-IL12A Antibody ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-01 Anti-IL12A Antibody (AMCA) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-02 Anti-IL12A Antibody (AP) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-03 Anti-IL12A Antibody (APC) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-04 Anti-IL12A Antibody (APC-Cy5.5) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-05 Anti-IL12A Antibody (APC-Cy7) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-06 Anti-IL12A Antibody (Avidin) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-07 Anti-IL12A Antibody (Biotin) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-08 Anti-IL12A Antibody (BPE) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-09 Anti-IL12A Antibody (Cy3) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-10 Anti-IL12A Antibody (Cy5) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-11 Anti-IL12A Antibody (Cy5.5) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)