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Interferons

Interferons, or IFNs, are proteins that are made and released in response to pathogens like viruses, bacteria, parasites, and cancer cells. Interferons play an important role as the first line of defense against infections. IFNs are part of the non-specific immune system. There are two main categories of interferons, type I and type II. Type I interferons are further divided into interferon-alpha and interferon-beta. Interferons-alpha are leukocyte interferons produced by virus-infected leukocytes. Interferon-beta is a fibroblast interferon produced by virus-infected fibroblasts. Type II interferons include gamma interferons which are produced by activated T-cells and NK cells in response to an antigen stimulation of lymphocytes. All types of interferons increase the expression of class I MHC molecules and gamma interferons increase the expression of class II MHC molecules. MHC (major histocompatibility complex) molecules are responsible for major immune responses and found in all upper level vertebrates. Certain viruses have developed immunity to interferons by producing proteins that can block interferons by binding to them and essentially inhibit the action of the interferon.

Anti-Plzf antibody binds against zinc finger protein 145. PLZF is a transcription factor that plays a role in myeloid maturation and development of other types of differentiated tissues. Plzf is a zinc finger protein localized in the nucleus of cells within the hematopoietic system. Plzf is expressed in bone marrow, early myeloid cell lines, peripheral blood cells, ovaries, kidney, and lungs. Defects in ZbTB16 are the cause of skeletal defects genital hypoplasia and mental retardation. Skeletal defects genital hypoplasia and mental retardation is a disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly, and short stature. Chromosome errors involving Plzf can cause acute promyelocytic leukemia. Acute promyelocytic leukemia (APL) is characterized by chromosomal translocation involving the retinoic acid receptor alpha. Anti-interferon gamma antibody binds against the target interferon gamma. As stated above, interferon gamma is produced by lymphocytes which have been activated by certain antigens or mitogens (or other cellular invaders). The gamma interferon is a type II interferon that has anti-viral capabilities as well as many other immunoregulatory functions. IFNG activates macrophages, has anti-proliferative effects, and can potentiate anti-viral or anti-tumor effects of type I interferons. Interferon gamma is secreted from activated T-lymphocytes. In Caucasians, genetic defects in gamma interferon are associated with the risk of aplastic anemia. Aplastic anemia is a condition that prevents the bone marrow from producing an adequate amount of new red blood cells. Affected individuals have low levels of red blood cells, white blood cells, and platelets.

 
Product Number Title Applications Host Clonality
AC21-2868 Anti-Interferon-activable protein 203 Antibody ELISA Goat Polyclonal
AC21-2961 Anti-IFNAR1 Antibody ELISA Goat Polyclonal
AC21-2962 Anti-IFNAR1 Antibody ELISA, WB Goat Polyclonal
AC21-2963 Anti-IFNAR1 Antibody ELISA, WB Goat Polyclonal
AC21-0084-01 Anti-TXK Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0084-02 Anti-TXK Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0084-03 Anti-TXK Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0084-04 Anti-TXK Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0084-05 Anti-TXK Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0084-06 Anti-TXK Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0084-07 Anti-TXK Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0084-08 Anti-TXK Antibody (BPE) ELISA, WB Goat Polyclonal