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Innate Immunity

Immunology is the study of the immune system and its functions. The immune system can function in either specific, adaptive ways or in innate or non-specific ways. While the adaptive immune system may take some time to mount a response to a bodily invader, the innate immune system is a preventative or immediate immune response. Innate or non-specific immune functions include first line of defense barriers like the skin, mucous membranes, and bodily secretions like saliva, tears, and sweat. Components of the innate immune system include anatomic barriers, humoral barriers, and cellular barriers. Anatomic barriers (mechanical, chemical, and biological factors) consist of the skin, tears, saliva, and cilia in the respiratory and digestive systems. Humoral barriers include the body's inflammation response, coagulation system, interferons, lysozymes, and interleukins. Cellular barriers like neutrophils, macrophages, dentritic cells, natural killer cells, and eosinophils help to further the body's immune response.

Anti-MyD88 Antibody binds against the MyD88 protein target. MyD88 is an adapter protein involved in the toll-like receptor and the IL-1 pathway in the innate immune system response. MyD88 action has involvement in cytokine secretion and the inflammatory response. MyD88 is ubiquitously expressed in the cytoplasm of all tissues in the body. Defects in MyD88 are the cause of recurrent pyogenic bacterial infections due to MyD88 deficiency. Pyogenic bacterial infections due to deficient MyD88 is an autosomal recessive disorder characterized by a susceptibility to an extensive array of pyogenic bacterial pathogens often leading to pneumococcal disease. Affected individuals typically have normal resistance and immune response to other types of microbes not from the pyogenic bacterial family. Anti-APOB antibody binds to apolipoprotein B. Defects in APOB cause a disorder called familial hypobetalipoproteinemia type 1. People suffering from this disorder have drastically reduced plasma concentrations, low density lipoproteins, and have trouble absorbing dietary fat.

 
Product Number Title Applications Host Clonality
AC16-0034 Anti-IL12A Antibody ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0041 Anti-Visfatin Antibody ELISA, WB, IHC(F), IHC(P) Rat Monoclonal (14A5)
AC16-0048 Anti-TNF Receptor I Antibody ELISA, WB, IHC(P), FC Rabbit Polyclonal
AC16-0058 Anti-F4/80 Antibody ELISA, WB, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (BM8)
AC16-0059 Anti-TNF Receptor I Antibody ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0060 Anti-TNF Receptor I Antibody WB, IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (utr1)
AC16-0034-01 Anti-IL12A Antibody (AMCA) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-02 Anti-IL12A Antibody (AP) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-03 Anti-IL12A Antibody (APC) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-04 Anti-IL12A Antibody (APC-Cy5.5) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-05 Anti-IL12A Antibody (APC-Cy7) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-06 Anti-IL12A Antibody (Avidin) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
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